Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame
Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame
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DOI：
10.1016/s0360-3016(01)02731-6
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发表时间：
2002-03-15
影响因子：
7
通讯作者：
Hiraoka, M
中科院分区：
文献类型：
--
作者：
Nagata, Y;Negoro, Y;Hiraoka, M
目的：本研究旨在评估使用立体定向身体框架对一个或两个肺部肿瘤进行三维（3D）适形大分割单次高剂量放射治疗的临床结果。方法和材料：本研究纳入了 40 名在 1998 年 7 月至 2000 年 11 月期间接受治疗并随访超过 10 个月的患者。 40名患者中，31名患有原发性肺癌，9名患有转移性肺癌。原发性肺癌分期为 T1N0M0、T2N0M0 和 T3N0M0 的患者分别为 19 例、8 例和 4 例。转移性肺癌的原发部位为结肠4例，舌2例，骨肉瘤、肺癌、肝细胞癌各1例。进行3D治疗计划以将目标剂量均匀性维持在15%以内，并将受照射的肺体积从>20 Gy减少到6个月，6个肿瘤（18%）在治疗后完全消失。治疗后，25 个肿瘤 (76%) 的大小缩小了 30% 或更多。因此，31 个肿瘤（94%）显示出局部反应。在 4-37 个月的随访期间（中位数 19），没有发现高于美国国家癌症研究所通用毒性标准 2 级的肺部并发症。在接受 48 Gy 照射的 16 名经组织学证实为 T1N0M0 原发性肺癌的患者中，所有肿瘤在 6-36 个月的随访期间均得到局部控制（中位数 = 19）。 9个肺转移瘤接受了总共48Gy的照射，其中2个肿瘤没有表现出局部反应。最后，在治疗后 3-29 个月（中位 18 个月）的随访期间，3 例（33%）肺转移肿瘤在治疗后 6-12 个月（中位 7 个月）局部复发。结论：使用立体定向体架进行 4 次 48 Gy 的 3D 适形大分割单次高剂量放射治疗对于治疗肺部肿瘤是有用的。 (C) 2002 爱思唯尔科学公司。
Purpose: This study was performed to evaluate the clinical outcomes of three-dimensional (3D) conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame.Methods and Materials: Forty patients who were treated between July 1998 and November 2000 and were followed for >10 months were included in this study. Of the 40 patients, 31 had primary lung cancer and 9 had metastatic lung cancer. The primary lung cancer was staged as T1N0M0, T2N0M0, and T3N0M0 in 19, 8, and 4 patients, respectively. The primary sites of metastatic lung cancer were the colon in 4, tongue in 2, and osteosarcoma, lung cancer, and hepatocellular carcinoma in 1 each. 3D treatment planning was performed to maintain the target dose homogeneity within 15% and to decrease the irradiated lung volume from >20 Gy to 6 months, 6 tumors (18%) disappeared completely after treatment. Twenty-five tumors (76%) decreased in size by 30% or more after treatment. Therefore, 31 tumors (94%) showed a local response. During the follow-up of 4-37 months (median 19), no pulmonary complications greater than National Cancer Institute-Common Toxicity Criteria Grade 2 were noted. Of the 16 patients with histologically confirmed T1N0M0 primary lung cancer who received 48 Gy, all tumors were locally controlled during the follow-up of 6-36 months (median = 19). In 9 tumors with lung metastases that were irradiated with 48 Gy in total, 2 tumors did not show a local response. Finally, 3 tumors (33%) with lung metastases relapsed locally at 6-12 months (median 7) after treatment during the follow-up of 3-29 months (median 18).Conclusion: 3D conformal hypofractionated single high-dose radiotherapy of 48 Gy in 4 fractions using a stereotactic body frame was useful for the treatment of lung tumors. (C) 2002 Elsevier Science Inc.