ACETAZOLAMIDE FOR TREATMENT OF CHRONIC MACULAR EDEMA IN RETINITIS PIGMENTOSA
ACETAZOLAMIDE FOR TREATMENT OF CHRONIC MACULAR EDEMA IN RETINITIS PIGMENTOSA
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DOI：
10.1001/archopht.1989.01070020519031
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发表时间：
1989-10-01
影响因子：
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通讯作者：
JAMPOL, LM
中科院分区：
文献类型：
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作者：
FISHMAN, GA;GILBERT, LD;JAMPOL, LM
在一项掩蔽的交叉研究中，12名患有视网膜色素变性和慢性黄斑水肿的患者被前瞻性地用乙酰唑胺或安慰剂治疗2周。在12名患者中，有10名患者在使用乙酰唑胺治疗后主观和客观视力均有改善。甚至在基线时视力达到20/25的患者以及存在超过10年的黄斑水肿的患者中也能看到改善。剂量为500 mg/d比250 mg/d更有效。6例(50%)患者的荧光素血管造影显示黄斑水肿减轻。血管造影术显示的改善主要是由于视网膜毛细血管渗漏较少，而不是脉络膜毛细血管通过视网膜色素上皮渗漏。一些患者的视力有所改善，但血管造影术中荧光素渗漏量没有明显变化。
Twelve patients with retinitis pigmentosa and chronic macular edema were prospectively treated for 2-week periods with acetazolamide or a placebo in a masked, crossover study. Ten of the 12 patients had both subjective and objective improvement in visual acuity when treated with acetazolamide. Improvement was seen even in patients with an acuity as good as 20/25 at baseline as well as in patients with macular edema present for more than a decade. A dosage of 500 mg/d was found to be more effective than 250 mg/d. Six patients (50%) showed lessening of their macular edema on fluorescein angiography. This angiographically demonstrated improvement was predominantly due to less detectable leakage from retinal capillaries rather than from choroidal capillaries through the retinal pigment epithelium. Improvement in visual acuity was seen in some patients without a detectable change in the amount of angiographic fluorescein leakage.