Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases.
Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases.
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DOI：
10.1002/wdev.279
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Ding L
中科院分区：
文献类型：
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作者：
Lee Y;Decker M;Lee H;Ding L
血液和免疫细胞的终身生成取决于造血干细胞（HSC）。它们的功能受到复杂分子网络的精确调节，这些分子网络整合并响应身体不断变化的生理需求。在过去的几年里，在理解HSC在发育和稳态过程中的外在调节方面取得了重大进展。在该领域技术进步的推动下，支持体内HSC的微环境的细胞和分子组分正在出现。此外，HSC与其微环境的相互作用被认为是许多血液疾病发病机制的关键因素。在这里，我们详细回顾了这些进展，并强调在发展，稳态和疾病的背景下，HSC的外在调节。造血干细胞（hematopoietic stem cells，HSCs）与其周围环境的相互作用对造血系统的发育、稳态和疾病至关重要。
Lifelong generation of blood and immune cells depends on hematopoietic stem cells (HSCs). Their function is precisely regulated by complex molecular networks that integrate and respond to ever changing physiological demands of the body. Over the past several years, significant advances have been made in understanding the extrinsic regulation of HSCs during development and in homeostasis. Propelled by technical advances in the field, the cellular and molecular components of the microenvironment that support HSCs in vivo are emerging. In addition, the interaction of HSCs with their niches is appreciated as a critical contributor to the pathogenesis of a number of hematological disorders. Here, we review these advances in detail and highlight the extrinsic regulation of HSCs in the context of development, homeostasis and diseases. The interaction between hematopoietic stem cells (HSCs) and their environment is critical for the hematopoietic system in development, homeostasis and diseases.
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影响因子：
23.9
作者：
Butler JM;Nolan DJ;Vertes EL;Varnum-Finney B;Kobayashi H;Hooper AT;Seandel M;Shido K;White IA;Kobayashi M;Witte L;May C;Shawber C;Kimura Y;Kitajewski J;Rosenwaks Z;Bernstein ID;Rafii S
通讯作者：
Rafii S
影响因子：
30.3
作者：
Burberry A;Zeng MY;Ding L;Wicks I;Inohara N;Morrison SJ;Núñez G
通讯作者：
Núñez G
影响因子：
64.8
作者：
Chen JY;Miyanishi M;Wang SK;Yamazaki S;Sinha R;Kao KS;Seita J;Sahoo D;Nakauchi H;Weissman IL
通讯作者：
Weissman IL
影响因子：
20.3
作者：
Abkowitz, JL;Golinelli, D;Guttorp, P
通讯作者：
Guttorp, P
影响因子：
82.9
作者：
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