Age differences in hippocampal subfield volumes from childhood to late adulthood.
Age differences in hippocampal subfield volumes from childhood to late adulthood.
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DOI：
10.1002/hipo.22517
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发表时间：
2016-02
期刊：
影响因子：
3.5
通讯作者：
Ofen N
中科院分区：
文献类型：
--
作者：
Daugherty AM;Bender AR;Raz N;Ofen N
海马由不同的子区域组成：四个角氨区（CA 1-CA 4），齿状回（DG）和下托。少数人海马子领域的体内研究表明，在健康的儿童发育和衰老过程中，各子领域的体积年龄差异程度不同。然而，在整个生命周期中，年龄和子字段体积之间的关联是未知的。在这里，我们使用了高分辨率成像技术，并手动测量海马子域和内嗅皮质体积在一个健康的寿命样本（N = 202），年龄8-82岁。各区域在数量上的年龄差异程度各不相同。合并CA 1 -2体积与年龄呈负线性相关。相反，年龄和CA 3-DG和内嗅皮层的体积之间的关联是负的，在童年中期和成年后期衰减。下托体积与年龄无关。不同的幅度和模式的年龄差异的子字段卷可能反映了动态的微观结构因素，并在整个生命周期的认知功能的影响。
The hippocampus is composed of distinct subfields: the four cornu ammonis areas (CA1–CA4), dentate gyrus (DG), and subiculum. The few in vivo studies of human hippocampal subfields suggest that the extent of age differences in volume varies across subfields during healthy childhood development and aging. However, the associations between age and subfield volumes across the entire lifespan are unknown. Here, we used a high-resolution imaging technique and manually measured hippocampal subfield and entorhinal cortex volumes in a healthy lifespan sample (N = 202), ages 8–82 years. The magnitude of age differences in volume varied among the regions. Combined CA1–2 volume evidenced a negative linear association with age. In contrast, the associations between age and volumes of CA3-DG and the entorhinal cortex were negative in mid-childhood and attenuated in later adulthood. Volume of the subiculum was unrelated to age. The different magnitudes and patterns of age differences in subfield volumes may reflect dynamic microstructural factors and have implications for cognitive functions across the lifespan.