AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis.
AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis.
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DOI：
10.1016/b978-0-12-401676-7.00003-6
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发表时间：
2013
影响因子：
--
通讯作者：
Fisher, Paul B.
中科院分区：
文献类型：
--
作者：
Emdad, Luni;Das, Swadesh K.;Dasgupta, Santanu;Hu, Bin;Sarkar, Devanand;Fisher, Paul B.
星形胶质细胞升高基因-1（AEG-1），也称为metadherin（MTDH）和富含赖氨酸的CEACAM 1共分离物（LYRIC），最初于2002年克隆。AEG-1/MTDH/LYRIC已成为一种重要的癌基因，在多种类型的人类癌症中过表达。对AEG-1/MTDH/LYRIC的扩展研究已经确定了该分子在肿瘤进展的几个关键方面的功能作用，包括转化、增殖、细胞存活、逃避凋亡、迁移和侵袭、转移、血管生成和化疗耐药性。AEG-1/MTDH/LYRIC在肿瘤发生和进展中的多功能作用与许多信号级联相关，最近的研究确定了AEG-1/MTDH/LYRIC在调节癌症促进和其他生物学功能中的几个重要相互作用伙伴。本文综述了AEG-1/MTDH/LYRIC功能与信号变化、相互作用伙伴和血管生成的关系，并强调了该分子的新观点，表明其可能成为各种癌症和其他疾病临床治疗的重要靶点。
Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002. AEG-1/MTDH/LYRIC has emerged as an important oncogene that is overexpressed in multiple types of human cancer. Expanded research on AEG-1/MTDH/LYRIC has established a functional role of this molecule in several crucial aspects of tumor progression, including transformation, proliferation, cell survival, evasion of apoptosis, migration and invasion, metastasis, angiogenesis, and chemoresistance. The multifunctional role of AEG-1/MTDH/LYRIC in tumor development and progression is associated with a number of signaling cascades, and recent studies identified several important interacting partners of AEG-1/MTDH/LYRIC in regulating cancer promotion and other biological functions. This review evaluates the current literature on AEG-1/MTDH/LYRIC function relative to signaling changes, interacting partners, and angiogenesis and highlights new perspectives of this molecule, indicating its potential as a significant target for the clinical treatment of various cancers and other diseases.