Evaluation of graft-host interface after penetrating keratoplasty using anterior segment optical coherence tomography
Evaluation of graft-host interface after penetrating keratoplasty using anterior segment optical coherence tomography
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DOI：
10.1007/s10384-014-0309-5
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发表时间：
2014-05-01
影响因子：
2.4
通讯作者：
Yoon, Kyung Chul
中科院分区：
文献类型：
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作者：
Sung, Mi Sun;Yoon, Kyung Chul
为探讨穿透性角膜移植(PKP)术后植片-宿主界面的特点，对49例49眼不同基础疾病(角膜瘢痕22眼、大泡性角膜病变14眼、圆锥角膜13眼)的穿透性角膜移植(PKP)进行了回顾性分析。所有患者均行AS-OCT检查，移植物-宿主连接的伤口轮廓分为对位连接、缝隙、台阶和突起。分析临床特征与创面形态的相关性，共分析49只眼392个移植物-宿主交界处。其中对位良好155段(39.5%)，错位237段(60.5%)。最常见的错位类型是突出(117个节段，占39.9%)。根据8个断面中最常见的排列方式对眼进行分类时，术前诊断组间排列方式差异有统计学意义(P=0.04)。球镜当量(P=0.04)和角膜屈光度散光(P<；0.01)在两组间有显著差异。植片-宿主厚度差异与角膜散光(r=0.56，P<；0.01)和移植物过大程度(r=0.29，P=0.04)显著相关。根据术前的临床诊断，PKP术后伤口界面的排列方式不同，与等值球面散光和角膜散光显著相关。
To evaluate the characteristics of the graft-host interface after penetrating keratoplasty (PKP) using anterior segment optical coherence tomography (AS-OCT).Forty-nine eyes of 49 patients with three different underlying diseases (corneal scar, 22 eyes; bullous keratopathy, 14 eyes; keratoconus, 13 eyes) who underwent PKP were retrospectively reviewed. AS-OCT was performed in all patients and wound profiles of the graft-host junctions were classified into well-apposed junction, gap, step, and protrusion. The correlations between clinical characteristics and wound profiles from the AS-OCT were analyzed.A total of 392 graft-host junctions from 49 eyes were analyzed. Among them, 155 sections (39.5 %) had well-apposed junctions and 237 sections (60.5 %) had malapposed junctions. The most frequent type of malapposition was protrusion (117 sections, 39.9 %). When categorizing the eyes according to the most frequent alignment type among the 8 cross-sections, the alignment pattern showed significant differences between the preoperative diagnosis groups (P = 0.04). Spherical equivalent (P = 0.04) and keratometric astigmatism (P < 0.01) showed significant differences between the alignment groups. Graft-host thickness disparities showed significant correlations with keratometric astigmatism (r = 0.56, P < 0.01) and degree of graft oversize (r = 0.29, P = 0.04).The alignment pattern of wound interface after PKP differed according to the clinical diagnosis before surgery and was significantly associated with spherical equivalent and keratometric astigmatism.