Relation between Presynaptic and Postsynaptic Dopaminergic Functions Measured by Positron Emission Tomography: Implication of Dopaminergic Tone
Relation between Presynaptic and Postsynaptic Dopaminergic Functions Measured by Positron Emission Tomography: Implication of Dopaminergic Tone
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DOI：
10.1523/jneurosci.6024-10.2011
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发表时间：
2011-05-25
影响因子：
5.3
通讯作者：
Suhara, Tetsuya
中科院分区：
文献类型：
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作者：
Ito, Hiroshi;Kodaka, Fumitoshi;Suhara, Tetsuya
突触前和突触后多巴胺能功能都可以通过正电子发射断层扫描（PET）来估计。虽然突触前和突触后多巴胺能功能都受到相应基因的调节并与人格特征相关，但突触前和突触后功能之间在个体差异方面的关系几乎没有被研究过。在本研究中，使用PET分别用[(11)C]雷氯必利和L-β-(11)C]多巴在同一健康受试者中测量纹状体多巴胺D(2)受体结合和内源性多巴胺合成率，并对这两个参数进行比较。对 14 名健康男性在休息状态下连续进行了两项使用 [(11)C] 雷氯必利和 L-β-(11)C] DOPA 的 PET 研究。对于[(11)C]雷氯必利PET，结合电位通过参考组织模型方法计算。对于L-β-(11)C]DOPAPET，通过图形分析估计内源性多巴胺合成率。多巴胺 D(2) 受体的结合电位与内源性多巴胺合成率之间存在显着负相关（r = -0.66，p < 0.05）。尽管[(11)C]雷氯必利结合电位的个体差异可能是由于个体间受体密度差异和突触间隙内源性多巴胺浓度差异造成的，但突触前和突触后功能参数之间的负相关可能表明两种功能之间存在补偿关系。
Both presynaptic and postsynaptic dopaminergic functions can be estimated by positron emission tomography (PET). While both presynaptic and postsynaptic dopaminergic functions would be regulated by corresponding genes and related to personality traits, the relation between presynaptic and postsynaptic functions in terms of interindividual variation has hardly been investigated. In the present study, both striatal dopamine D(2) receptor binding and endogenous dopamine synthesis rate were measured in the same healthy subjects using PET with [(11)C]raclopride and L-[beta-(11)C]DOPA, respectively, and these two parameters were compared. Two PET studies with [(11)C] raclopride and L-[beta-(11)C] DOPA were performed sequentially at rest condition on 14 healthy men. For [(11)C] raclopride PET, the binding potential was calculated by the reference tissue model method. For L-[beta-(11)C]DOPAPET, the endogenous dopamine synthesis rate was estimated by graphical analysis. A significant negative correlation was observed between the binding potential of dopamine D(2) receptors and endogenous dopamine synthesis rate (r = -0.66, p < 0.05). Although the interindividual variation of binding potential of [(11)C] raclopride would be due to both the interindividual difference in the receptor density and that in the concentration of endogenous dopamine in the synaptic cleft, the negative correlation between parameters for both presynaptic and postsynaptic functions might indicate a compensative relation between the two functions.