An evaluation of the differential from the Abbott CD 3500 in a population of patients with haematological abnormalities.
An evaluation of the differential from the Abbott CD 3500 in a population of patients with haematological abnormalities.
复制标题
在血液学异常患者群体中评估与 Abbott CD 3500 的差异。
DOI：
10.1111/j.1365-2257.1997.tb00006.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. Henniker
中科院分区：
文献类型：
--
作者：
J. Iles;J. Henniker
Cell Dyn 3500 （CD 3500）血液学分析仪（Abbott Diagnostics, Lane Cove， NSW, Australia）已被评估，以确定已知血液学异常患者群体中鉴别和白细胞可疑标记的可靠性。评估包括白细胞鉴别参数的评估，以及白细胞可疑标记的敏感性、特异性和效率。该研究表明，cd3500是一种有效和敏感的筛查工具，用于检测临床上显著的白细胞异常的存在。一般来说，Blast和Band标志显示出最高水平的假阳性标记（最低灵敏度）。未成熟的粒细胞标志被发现是一个非常可靠的指示存在的髓细胞，变髓细胞和早幼粒细胞在膜上。有0.4%的假阴性率，其中cd3500在单独标记时未检测到显著数量的变异淋巴细胞（bbb10 %）。当分析仪标记和白细胞分散分布与定义的实验室限制相结合时，所有白细胞可疑标记都具有可接受的灵敏度、特异性和效率。
The Cell Dyn 3500 (CD 3500) Haematology Analyser (Abbott Diagnostics, Lane Cove, NSW, Australia) has been evaluated to determine the reliability of the differential and white cell suspect flagging in a population of patients with known haematological abnormalities. The evaluation included the assessment of white cell differential parameters in addition to sensitivity, specificity and efficiency of white cell suspect flagging. The study showed that the CD 3500 is an efficient and sensitive screening tool for detecting the presence of clinically significant white cell abnormalities. Generally, the Blast and Band flags demonstrated the highest level of false positive flagging (lowest sensitivity). The immature granulocyte flag was found to be an extremely reliable indicator of the presence of myelocytes, metamyelocytes and promyelocytes on the film. There was a 0.4% false negative rate where significant numbers of variant lymphocytes (> 10%) were not detected by the CD 3500 on flagging alone. When analyser flags and white cell scatter distribution are considered in combination with defined laboratory limits, all white cell suspect flags have acceptable sensitivity, specificity and efficiency rates.