Palladium-catalyzed intramolecular cyanoamidation of alkynyl and alkenyl cyanoformamides
Palladium-catalyzed intramolecular cyanoamidation of alkynyl and alkenyl cyanoformamides
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DOI：
10.1021/ol060733
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发表时间：
2006-06-22
期刊：
影响因子：
5.2
通讯作者：
Takemoto, Yoshiji
中科院分区：
文献类型：
--
作者：
Kobayashi, Yusuke;Kamisaki, Haruhi;Takemoto, Yoshiji
通过钯催化的炔基氰基甲酰胺的氰基酰胺化以45-99%的产率制备五至七元α-亚烷基内酰胺。反应完全以5-exo模式进行，得到相应的（Z）-烯烃作为主要产物。该反应也适用于1，1-二取代烯烃，得到带有季碳中心的羟吲哚。
The five- to seven-membered alpha-alkylidene lactams were prepared in 45-99% yield by the palladium-catalyzed cyanoamidation of alkynyl cyanoformamides. The reaction proceeded exclusively in a 5-exo mode, giving the corresponding (Z)-alkenes as major products. The reaction was also applied to 1,1-disubstituted alkenes to afford oxindoles bearing a quaternary carbon center.