Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms.
Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms.
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DOI：
10.1016/j.biopsych.2015.05.010
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发表时间：
2015-11-01
影响因子：
10.6
通讯作者：
Williamson DE
中科院分区：
文献类型：
--
作者：
Hanson JL;Hariri AR;Williamson DE
情感忽视与多种负面结果有关，特别是抑郁症的风险增加。出于越来越多的证据奖励相关的腹侧纹状体（VS）功能障碍的抑郁症，我们调查的作用，发展变化的VS活动出现抑郁症的情感忽视的功能。我们研究了106名参与者的奖励相关VS活动的纵向神经成像，情绪评估和情绪忽视测量之间的关系，这些参与者首先在11-15岁之间进行扫描，然后在两年后进行扫描。我们发现，更高水平的情感忽视与第一次和第二次评估之间的奖励相关VS活动的迟钝发展相关（如较低的剩余变化分数所示）。此外，我们发现，这种奖励相关的VS活动的减少与更大的抑郁症相关，并部分介导了情感忽视和随后的抑郁症之间的关联。我们的研究结果提供了一个重要的证明，钝发展的奖励相关的VS活动作为一个功能的情感忽视预测抑郁症状的出现在青少年。此外，我们的研究结果与奖励相关VS功能障碍在抑郁症病因学和病理生理学中的重要性的新证据一致。这些结果是通过针对特定神经表型开发预测、预防和治疗压力相关精神病理学能力的第一步。
Emotional neglect is associated with multiple negative outcomes, particularly increased risk for depression. Motivated by increasing evidence of reward-related ventral striatum (VS) dysfunction in depression, we investigated the role of developmental changes in VS activity on the emergence of depressive symptomatology as a function of emotional neglect. We examined relationships between longitudinal neuroimaging of reward-related VS activity, assessments of mood, and measures of emotional neglect in 106 participants first scanned between ages 11–15 and then two years later. We found that greater levels of emotional neglect were associated with blunted development of reward-related VS activity between the first and second assessments (as indexed by lower residualized change scores). Additionally, we found that decreases in this reward-related VS activity were related to greater depressive symptomatology, and partially mediated the association between emotional neglect and subsequent depressive symptomatology. Our results provide an important demonstration that blunted development of reward-related VS activity as a function of emotional neglect predicts the emergence of depressive symptoms in adolescents. Further, our results are consistent with emerging evidence for the importance of reward-related VS dysfunction in the etiology and pathophysiology of depression. These results are a first step toward developing the ability to predict, prevent, and treat stress-related psychopathology through the targeting of specific neural phenotypes.