Deficient interference control during working memory updating in adults with ADHD: An event-related potential study
Deficient interference control during working memory updating in adults with ADHD: An event-related potential study
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DOI：
10.1016/j.clinph.2015.05.021
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发表时间：
2016-01
影响因子：
4.7
通讯作者：
D. Stroux;A. Shushakova;A. Shushakova;A. J. Geburek-Höfer;Patricia Ohrmann;Fred Rist;A. Pedersen;A. Pedersen
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文献类型：
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作者：
D. Stroux;A. Shushakova;A. Shushakova;A. J. Geburek-Höfer;Patricia Ohrmann;Fred Rist;A. Pedersen;A. Pedersen
目的 对于患有注意缺陷多动障碍 (ADHD) 的成人工作记忆 (WM) 表现不佳的潜在机制知之甚少。本研究利用事件相关电位研究 WM 更新过程中的干扰和负载效应。方法 40 名 ADHD 患者和 41 名对照者在低和高 WM 负载条件下执行言语背任务。在 WM 处理过程中，使用入侵探针（即诱饵）来挑战干扰控制能力。结果与健康对照相比，诱饵试验中 ADHD 成人的刺激依赖性 N200 振幅调制和行为表现均有所降低。此外，ADHD 患者的 P300 振幅往往对 WM 负荷不太敏感。结论我们的研究结果为刺激类别的不准确辨别提供了电生理学证据。特别是，干扰控制不足可能会导致患有 ADHD 的成人受试者出现明显的 WM 缺陷。意义当前的研究结果有助于更深入地了解成人 ADHD 执行功能障碍的神经基础，重点关注 WM 领域。
ObjectiveLittle is known about the underlying mechanisms of poor working memory (WM) performance of adults with attention deficit hyperactivity disorder (ADHD). This study investigates interference and load effects during WM updating by use of event-related potentials.MethodForty ADHD patients and 41 controls performed verbaln-back tasks under conditions of low and high WM load. Intrusion probes, i.e., lures, were implemented to challenge interference control abilities during WM processing.ResultsStimulus-dependent N200 amplitude modulation and behavioral performance in lure trials were reduced in adults with ADHD compared to healthy controls. Also, P300 amplitudes tended to be less sensitive to WM load in patients with ADHD.ConclusionOur findings provide electrophysiological evidence for inaccurate discrimination of stimulus categories. Particularly, deficient interference control may lead to overt WM deficits in adult subjects with ADHD.SignificanceThe current findings contribute to a deeper understanding of the neural substrates of executive dysfunction in adult ADHD, focusing on the domain of WM.