Challenges of imaging interpretation to predict oligodendroglioma grade: a report from the Neuro-Oncology Branch.
Challenges of imaging interpretation to predict oligodendroglioma grade: a report from the Neuro-Oncology Branch.
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DOI：
10.2217/cns-2021-0005
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发表时间：
2022-03-01
期刊：
影响因子：
--
通讯作者：
Penas-Prado M
中科院分区：
文献类型：
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作者：
Aboud O;Shah R;Vera E;Burton E;Theeler B;Wu J;Boris L;Quezado M;Reyes J;Wall K;R Gilbert M;S Armstrong T;Penas-Prado M
说明转诊中心就诊的少突胶质细胞瘤患者的影像学解释的挑战，并评估评估者间的可靠性。两名神经肿瘤学家回顾了少突胶质细胞瘤患者的诊断性放疗前MRI;使用kappa系数（k）计算评价者间可靠性。神经放射科医生测量了术前表观扩散系数（ADC）（如果有的话）。在58名患者中的4名中观察到广泛增强，k = 0.7;在58名患者中的7名中观察到坏死，k = 0.61;在17名患者中的7名中观察到钙化，k = 1.0;在39名患者中的2名中观察到扩散受限，k = 1.0（均为3级）。ADC值与曲线下面积的受试者操作者特征分析为0.473，与零假设无显著差异（p = 0.14）。在我们的样本中，广泛增强、坏死和钙化与3级少突胶质细胞瘤相关。然而，在评估放射学特征时，评估者间的差异是一个重要的限制，支持成像协议及其解释标准化的需要。
To illustrate challenges of imaging interpretation in patients with oligodendroglioma seen at a referral center and evaluate interrater reliability. Two neuro-oncologists reviewed diagnostic preradiation MRIs of oligodendroglioma patients; interrater reliability was calculated with the kappa coefficient (k). A neuroradiologist measured presurgical apparent diffusion coefficient (ADC), if available. Extensive enhancement was noted in four of 58 patients, k = 0.7; necrosis in seven of 58, k = 0.61; calcification in seven of 17, k = 1.0; diffusion restriction in two of 39 patients, k = 1.0 (all only in grade 3). ADC values with receiver operator characteristic analysis for area under the curve were 0.473, not significantly different from the null hypothesis (p = 0.14). Extensive enhancement, necrosis and calcification correlated with grade 3 oligodendroglioma in our sample. However, interrater variability is an important limitation when assessing radiographic features, supporting the need for standardization of imaging protocols and their interpretation.