Lessons from the first year of the WAIVE study investigating the protective effect of influenza vaccine against laboratory-confirmed influenza in hospitalised children aged 6-59 months
Lessons from the first year of the WAIVE study investigating the protective effect of influenza vaccine against laboratory-confirmed influenza in hospitalised children aged 6-59 months
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DOI：
10.1111/j.1750-2659.2010.00141.x
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发表时间：
2010-07-01
影响因子：
4.4
通讯作者：
Richmond, Peter C.
中科院分区：
文献类型：
--
作者：
Dixon, Gabriela A.;Moore, Hannah C.;Richmond, Peter C.
背景流感是儿科住院的主要原因。流感疫苗提供给所有儿童年龄6-59个月居住在西澳大利亚州在2008年，我们希望评估这种免疫programme.ObjectivesTo评估的实用性巢式匹配病例对照设计，以估计灭活流感疫苗接种的保护作用，在住院儿童年龄6-59个月。而匹配的对照组是从因急性非呼吸道疾病入院的儿童中招募的。我们估计流感疫苗对流感的有效性（VE）为1 -调整后的优势比，从多变量logistic regression.ResultsThe 2008年流感季节的特点是晚高峰和流感病毒B的优势。我们招募了26名实验室确诊的流感住院患者和50名匹配的对照。谁是完全接种疫苗的情况下的比例为7%与30%的控制调整VE为83%（95%CI-54至98）。ConclusionsRecruiting足够的控制是有问题的，在未来，我们将选择控制住院的流感样疾病，但流感阴性实验室PCR检测。VE估计值较高但不显著，反映了病例数较少。
BackgroundInfluenza is major cause of paediatric hospitalisation. Influenza vaccine was offered to all children aged 6-59 months resident in Western Australia in 2008, and we wished to evaluate the effectiveness of this immunisation programme.ObjectivesTo assess the practicalities of a nested matched case-control design to estimate the protective effect of inactivated influenza vaccination in hospitalised children aged 6-59 months.MethodsCases were hospitalised children with laboratory-confirmed influenza, while matched controls were recruited from children admitted for an acute non-respiratory illness. We estimated influenza vaccine effectiveness (VE) against influenza as 1 - the adjusted odds ratio from multivariate logistic regression.ResultsThe 2008 influenza season was characterised by a late peak and a predominance of influenza virus B. We recruited 26 hospitalised patients with laboratory-confirmed influenza and 50 matched controls. The proportion of cases who were fully vaccinated was 7% versus 30% of controls giving an adjusted VE of 83% (95% CI -54 to 98).ConclusionsRecruiting sufficient controls was problematic and in the future, we will select controls hospitalised for an influenza-like-illness but influenza negative by laboratory PCR testing. The VE estimate was high but non-significant, reflecting the low number of cases.