THE EPIDEMIOLOGY OF MULTIPLE-SCLEROSIS IN 3 AUSTRALIAN CITIES - PERTH, NEWCASTLE AND HOBART
THE EPIDEMIOLOGY OF MULTIPLE-SCLEROSIS IN 3 AUSTRALIAN CITIES - PERTH, NEWCASTLE AND HOBART
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DOI：
10.1093/brain/111.1.1
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发表时间：
1988-02-01
期刊：
影响因子：
14.5
通讯作者：
MCCALL, MG
中科院分区：
文献类型：
--
作者：
HAMMOND, SR;MCLEOD, JG;MCCALL, MG
在澳大利亚的三个城市，珀斯、纽卡斯尔和霍巴特进行了多发性硬化症（MS）的流行病学调查，其流行日为1981年6月30日的全国人口普查日，正好是同一城市上次调查的20年后。本研究证实了1961年调查中发现的患病率增加与南纬度增加之间的关系。在两项研究之间的20年里，患病率显著增加。在同一时期，纽卡斯尔和霍巴特的发病率也有所增加，但珀斯的发病率基本保持稳定，尽管这些变化并不显著。流行率的上升是由于每个城市不同重要性的因素的组合。这些因素包括更好的情况下确定，提高认识的不太严重的残疾患者，增加生存时间和差异移民的人口在发展MS的风险高于土著人口。最后，对珀斯和霍巴特移民人群MS患病率的分析表明，MS的患病风险可能比普遍接受的年龄范围更广，或者在前城市流行的环境因素改变了疾病的表达。
An epidemiological survey of multiple sclerosis (MS) in three Australian cities, Perth, Newcastle and Hobart, was undertaken with its prevalence day being the national census day on June 30, 1981, exactly twenty years after a previous survey of the same cities. The relationship between increasing prevalence and increasing south latitude found in the 1961 survey was confirmed in this present study. Prevalence rates had increased significantly over the twenty years between the studies. Over the same time period incidence rates had also increased in Newcastle and Hobart but had remained essentially stable in Perth although these changes were not significant. The rise in prevalence was due to a combination of factors of differing importance in each city. These factors included better case ascertainment, increased recognition of the less severely disabled patient, increased survival time and differential immigration of a population at a higher risk of developing MS than the indigenous population. Finally, analysis of MS prevalence rates among migrant populations in Perth and Hobart suggested that either the risk of acquisition of MS may extend over a wider age range than is generally accepted or that environmental factors prevalent in the former city have modified disease expression there.