The Potential of Silk and Silk-Like Proteins as Natural Mucoadhesive Biopolymers for Controlled Drug Delivery.
The Potential of Silk and Silk-Like Proteins as Natural Mucoadhesive Biopolymers for Controlled Drug Delivery.
复制标题
丝绸和丝绸样蛋白作为天然粘附生物聚合物的潜力，用于控制药物。
DOI：
10.3389/fchem.2015.00065
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发表时间：
2015
影响因子：
5.5
通讯作者：
Brooks AE
中科院分区：
文献类型：
--
作者：
Brooks AE
由于大的表面积，穿过粘膜的药物递送是特别有效的施用途径。然而，粘膜处存在的独特环境需要改变药物制剂，其被设计为（1）递送敏感的生物分子，（2）促进粘膜和药物之间的紧密接触，和（3）延长药物的局部停留时间。因此，制药工业对围绕使用粘膜粘附聚合物配制的药物递送系统感兴趣。粘膜粘附聚合物，无论是合成的还是生物的，都有用于局部药物递送的历史。在文献中突出的特征是壳聚糖、藻酸盐和纤维素衍生物。最近，丝和丝样衍生物已被探索其作为粘膜粘附聚合物的潜力。蚕和蜘蛛都产生粘性的丝样胶物质，分别是丝胶蛋白和聚集丝，这可能证明是一种有效的天然基质，用于将药物递送到粘膜。这篇小综述将探讨丝和丝样衍生物作为生物相容性粘膜粘附聚合物基质用于局部控制药物递送的潜力。
Drug delivery across mucus membranes is a particularly effective route of administration due to the large surface area. However, the unique environment present at the mucosa necessitates altered drug formulations designed to (1) deliver sensitive biologic molecules, (2) promote intimate contact between the mucosa and the drug, and (3) prolong the drug's local residence time. Thus, the pharmaceutical industry has an interest in drug delivery systems formulated around the use of mucoadhesive polymers. Mucoadhesive polymers, both synthetic and biological, have a history of use in local drug delivery. Prominently featured in the literature are chitosan, alginate, and cellulose derivatives. More recently, silk and silk-like derivatives have been explored for their potential as mucoadhesive polymers. Both silkworms and spiders produce sticky silk-like glue substances, sericin and aggregate silk respectively, that may prove an effective, natural matrix for drug delivery to the mucosa. This mini review will explore the potential of silk and silk-like derivatives as a biocompatible mucoadhesive polymer matrix for local controlled drug delivery.