Binary and microsatellite polymorphisms of the Y-chromosome in the Mbenzele Pygmies from the Central African Republic
Binary and microsatellite polymorphisms of the Y-chromosome in the Mbenzele Pygmies from the Central African Republic
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DOI：
10.1002/ajhb.10236
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Tyler-Smith, C
中科院分区：
文献类型：
--
作者：
Coia, V;Caglià, A;Tyler-Smith, C
本研究分析了中非共和国姆本泽勒俾格米人的6个二元多态性和6个微卫星的变异。5个不同的单倍群(B2b， E(xE3a), E3a， P和BR(xB2b，DE，P))，频率范围为0.022（单倍群，P） ~ 0.609（单倍群E3a）。单倍群频率的比较表明，Mbenzele人和Biaka俾格米人之间具有密切的遗传亲缘关系，这一发现与两个种群的共同起源和地理邻近性相一致。单倍群P、BR（xB2b、DE、P）和E（xE3a）在撒哈拉以南非洲罕见，在欧亚大陆西部常见，频率范围为0.022 ~ 0.087（单倍群E(xE3a)）。检测到30种不同的微卫星单倍型，频率范围为0.022 ~ 0.152。姆本泽勒人与比阿卡俾格米人共享微卫星单倍型的比例最高。姆本泽勒人和比亚卡俾格米人共有的7个单倍型中有5个属于E3a单倍群，这表明他们是班图人的后裔。利用微卫星数据计算的基于F-st遗传距离的图提供了一幅种群关系图，该图与利用单倍群频率获得的图部分一致，部分互补。最后，我们发现Mbenzele和Biaka俾格米人在y染色体上的基因相似性明显高于常染色体微卫星。我们认为这可能是由于y染色体较高的系统发育稳定性和班图人扩张过程中男性偏倚基因流的影响。(C) 2003 Wiley-Liss, Inc。
This study analyzes the variation of six binary polymorphisms and six microsatellites in the Mbenzele Pygmies from the Central African Republic. Five different haplogroups (B2b, E(xE3a), E3a, P and BR(xB2b,DE,P)) were observed, with frequencies ranging from 0.022 (haplogroup, P) to 0.609 (haplogroup E3a). A comparison of haplogroup frequencies indicates a close genetic affinity between the Mbenzele and the Biaka Pygmies, a finding consistent with the common origin and the geographical proximity of the two populations. The haplogroups P, BR(xB2b,DE,P) and E(xE3a), which are rare in sub-Saharan Africa but common in western Eurasia, were observed with frequencies ranging from 0.022 (haplogroup P) to 0.087 (haplogroup E(xE3a)). Thirty different microsatellite haplotypes were detected, with frequencies ranging from 0.022 to 0.152. The Mbenzele share the highest percent of microsatellite haplotypes with the Biaka Pygmies. Five out seven haplotypes which are shared by the Mbenzele and Biaka Pygmies belong to haplogroup E3a, which suggests that they are of Bantu origin. The plot based on F-st genetic distances calculated using microsatellite data provides a picture of population relationships which,is in part congruent and in part complementary to that obtained using haplogroup frequencies. Finally, the Mbenzele and Biaka Pygmies were found to be markedly more genetically similar using Y-chromosomal than autosomal microsatellites. We suggest that this could be due to the higher phylogenetic stability of Y-chromosome and to the effect of the male-biased gene flow during the Bantu expansion. (C) 2003 Wiley-Liss, Inc.