Endothelial Cell Density after Descemet Membrane Endothelial Keratoplasty: 1-to 2-Year Follow-up
Endothelial Cell Density after Descemet Membrane Endothelial Keratoplasty: 1-to 2-Year Follow-up
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DOI：
10.1016/j.ajo.2009.04.025
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发表时间：
2009-10-01
影响因子：
4.2
通讯作者：
Melles, Gerrit R. J.
中科院分区：
文献类型：
--
作者：
Ham, Lisanne;van Luijk, Chantal;Melles, Gerrit R. J.
目的：评价Descemet膜内皮角膜移植术（DMEK）后供体内皮细胞密度（ECD）。设计：非随机、前瞻性临床研究。方法：在一组因Fuchs内皮营养不良或假性瞳孔大疱性角膜病变而接受DMEK治疗的患者中，有26例患者进行了6个月和12个月的随访，其中7例也进行了24个月的随访。结果：随访24个月的组，术前ECD平均为2700（+/- 260）个细胞/mm(2)，术后6个月为2200（+/- 460）个细胞/mm(2)，术后12个月为2050（+/- 330）个细胞/mm(2)，术后24个月为1780（+/- 390）个细胞/mm(2)。随访12个月的组，术前ECD平均为2620（+/- 210）个细胞/mm(2)，术后6个月为1850（+/- 540）个细胞/mm(2)，术后12个月为1680（+/- 550）个细胞/mm(2)。在两组中，ECD在术前和6个月测量期间显著下降（P < 0.05）。结论：与早期内皮角膜成形术类似，DMEK可能与术后早期供体ECD降低约25%有关。[J]中华眼科杂志，2009;48(4):521-527。(C) 2009年Elsevier Inc.版权所有。)
PURPOSE: To evaluate donor endothelial cell density (ECD) after Descemet membrane endothelial keratoplasty (DMEK).DESIGN: Nonrandomized, prospective clinical study.METHODS: From a larger group of patients who underwent DMEK for Fuchs endothelial dystrophy or pseudophakic bullous keratopathy, complete ECD measurements were available of 26 patients with 6 and 12 months of follow-up, of whom 7 also had 24 months of follow-up.RESULTS: For the group with 24 months of follow-up, ECD averaged 2700 (+/- 260) cells/mm(2) before surgery, 2200 (+/- 460) cells/mm(2) at 6 months after surgery, 2050 (+/- 330) cells/mm(2) at 12 months after surgery, and 1780 (+/- 390) cells/mm(2) at 24 months after surgery. For the group with 12 months of follow-up, ECD averaged 2620 (+/- 210) cells/mm(2) before surgery, 1850 (+/- 540) cells/mm(2) at 6 months after surgery, and 1680 (+/- 550) cells/mm(2) at 12 months after surgery. In both groups, the ECD decreased significantly between the preoperative and 6-month measurement (P < .05).CONCLUSIONS: Similar to earlier endothelial kerato, plasty techniques, DMEK may be associated with a decrease in donor ECD of approximately 25% in the early postoperative phase. (Am J Ophthalmol 2009;148:521-527. (C) 2009 by Elsevier Inc. All rights reserved.)