De novo alveolar bone formation adjacent to endosseous implants -: A model study in the dog
De novo alveolar bone formation adjacent to endosseous implants -: A model study in the dog
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DOI：
10.1034/j.1600-0501.2003.00972.x
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发表时间：
2003-06-01
影响因子：
4.3
通讯作者：
Lindhe, J
中科院分区：
文献类型：
--
作者：
Berglundh, T;Abrahamsson, I;Lindhe, J
目的：描述一种用于研究伤口愈合不同阶段的模型。材料和方法：用于研究早期愈合的种植体具有与具有SLA表面结构的实心螺纹式种植体相对应的几何形状。在螺纹区内已准备了一周向槽。(骨内部分)，建立了一个几何上明确的伤口间隔。20只拉布拉多犬总共接受了160个实验装置，以评估2小时至12周的愈合情况。从不同的种植体部位制备基础切片和脱钙切片。结果：所使用的实验室有利于骨形成早期阶段的研究。研磨切片概述了软组织和硬组织形成的各个阶段，而脱钙的薄切片使我们能够更详细地研究骨组织建模和重塑过程中涉及的事件。最初空的创口腔被凝结物和肉芽组织占据，取而代之的是临时基质。骨形成过程在第一周就已经开始了。新生骨出现在切开骨床的侧缘，与母骨呈连续状，但在距母骨较远的SLA表面也可见编织骨。这种包括编织骨小梁的初级骨被平行纤维和/或板层骨和骨髓取代。在1-2周内，负责装置基本机械稳定性的节段区外侧的骨组织被吸收，并被新形成的有活力的骨取代。尽管暂时失去了硬组织接触，种植体在临床上始终保持稳定。结论：骨整合在其建立和维护过程中都是一个动态的过程。在建立阶段，接触区域(钛体和矿化骨之间)的骨吸收和非接触区域的骨形成之间存在着微妙的相互作用。在维护阶段，通过持续的改建和对功能的适应来确保骨整合。
Objective: To describe a model for the investigation of different phases of wound healing that are involved in the process resulting in osseointegration.Material and methods: The implants used for the study of early healing had a geometry that corresponded to that of a solid screw implant with an SLA surface configuration. A circumferential trough had been prepared within the thread region. (intra-osseous portion) that established a geometrically well-defined wound compartment. Twenty Labrador dogs received 160 experimental devices totally to allow the evaluation of healing between 2 h and 12 weeks. Both ground sections and decalcified sections were prepared from different implant sites.Results: The experimental chamber used appeared to be conducive for the study of early phases of bone formation. The ground sections provided an overview of the various phases of soft and hard tissue formation, while the decalcified, thin sections enabled a more detailed study of events involved in bone tissue modeling and remodeling. The initially empty wound chamber became occupied with a coagulum and a granulation tissue that was replaced by a provisional matrix. The process of bone formation started already during the first week. The newly formed bone present at the lateral border of the cut bony bed appeared to be continuous with the parent bone, but woven bone was also found on the SLA surface at a distance from the parent bone. This primary bone that included trabeculae of woven bone was replaced by parallel-fibered and/or lamellar bone and marrow. Between 1 and 2 weeks, the bone tissue immediately lateral to the pitch region, responsible for primary mechanical stability of the device, became resorbed and replaced with newly formed viable bone. Despite this temporary loss of hard tissue contact, the implants remained clinically stable at all times.Conclusion: Osseointegration represents a dynamic process both during its establishment and its maintenance. In the establishment phase, there is a delicate interplay between bone resorption in contact regions (between the titanium body and mineralized bone) and bone formation in 'contact-free' areas. During the maintenance phase, osseointegration is secured through continuous remodeling and adaptation to function.