Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex
Influences of rewarding and aversive outcomes on activity in macaque lateral prefrontal cortex
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DOI：
10.1016/j.neuron.2006.08.031
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发表时间：
2006-09-21
期刊：
影响因子：
16.2
通讯作者：
Sakagami, Masamichi
中科院分区：
文献类型：
--
作者：
Kobayashi, Shunsuke;Nomoto, Kensaku;Sakagami, Masamichi
食欲和厌恶的结果都可以加强动物的行为。然而，目前尚不清楚，这两种相反的神经元是由特定的还是共同的神经机制处理的。为了研究这个问题，我们研究了猕猴，执行记忆引导扫视任务的三个不同的结果，即交付液体奖励，避免空气喷，和反馈声音。动物在奖励试验中表现最好，在厌恶试验中表现居中，在只有声音的试验中表现最差。大多数任务相关的活动，在外侧前额叶皮层的差异影响的任务。厌恶性回避对某些前额叶神经元有明显的影响，尽管奖励的影响更为常见。我们还观察到神经元调制的积极和消极的抑制剂，反映强化或注意过程。我们的研究结果表明，有关积极和消极的情绪刺激的信息在前额叶皮层的差异，这可能有助于该结构在目标导向行为的作用。
Both appetitive and aversive outcomes can reinforce animal behavior. It is not clear, however, whether the opposing kinds of reinforcers are processed by specific or common neural mechanisms. To investigate this issue, we studied macaque monkeys that performed a memory-guided saccade task for three different outcomes, namely delivery of liquid reward, avoidance of air puff, and feedback sound only. Animals performed the task best in rewarded trials, intermediately in aversive trials, and worst in sound-only trials. Most task-related activity in lateral prefrontal cortex was differentially influenced by the reinforcers. Aversive avoidance had clear effects on some prefrontal neurons, although the effects of rewards were more common. We also observed neurons modulated by both positive and negative reinforcers, reflecting reinforcement or attentional processes. Our results demonstrate that information about positive and negative reinforcers is processed differentially in prefrontal cortex, which could contribute to the role of this structure in goal-directed behavior.