Dedicated donor unit transfusions reduces donor exposure in pediatric surgery patients.
Dedicated donor unit transfusions reduces donor exposure in pediatric surgery patients.
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DOI：
10.4103/ajts.ajts_57_16
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发表时间：
2017-07
影响因子：
--
通讯作者：
Rao KLN
中科院分区：
文献类型：
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作者：
Arora S;Marwaha N;Dhawan HK;Rao KLN
人们已经探索了许多策略来减少新生儿的多重供体暴露，例如使用限制性输血方案、限制医源性失血、使用重组促红细胞生成素和单一供体计划。在我们的研究中，我们评估了专用单一供体单位的可行性，并为接受手术的特定新生儿/婴儿保留来自同一供体的所有组件，并估计供体暴露的减少。前瞻性研究组纳入了 50 例接受手术的新生儿，并将输血细节与具有相同纳入标准的 50 例回顾性病例进行比较。术中失血量 >13 ml/Kg 与术中最常进行的输血显着相关（P <0.05）。研究组总体输血的供体暴露率为 1.15，而回顾性对照组为 4.03。在研究组中，供体暴露率（DER）：输血率（TR）比率为1：1.5，每供体单位输血量（TPDU）为1.5，这意味着与回顾性对照组相比，一个供体单位为每位患者贡献了1.5次输血，并导致每位患者的供体暴露减少了50%。我们的研究表明，通过实行专用供体单位输血政策，对于接受手术的新生儿，我们可以显着减少供体暴露。
Many strategies have been explored to reduce multiple donor exposures in neonates such as use of restrictive transfusion protocols, limiting iatrogenic blood loss, use of recombinant erythropoietin and single donor programs. In our study we assessed the feasibility of dedicating single donor units with reserving all the components from the same donor for the specified neonates/infants undergoing surgery and estimating reduction of donor exposure. Fifty neonates undergoing surgery were included in the prospective study group and the transfusion details were compared with 50 retrospective cases with same inclusion criteria. An intra-operative blood loss of >13 ml/Kg was significantly associated with transfusion (P <0.05) which was most frequently administered in the intra-operative period. Donor exposure rate of overall transfusion was 1.15 in the study group as compared to 4.03 in the retrospective control group. In study group Donor Exposure Rate (DER): Transfusion Rate (TR) ratio was 1:1.5 and Transfusion per Donor Unit (TPDU) of 1.5, means that one donor unit contributed to 1.5 transfusions in each patient and contributed to 50% reduction in donor exposure in each patient as compared to retrospective control group. Our study showed that by practicing dedicated donor unit transfusion policy, for neonates undergoing surgery we could significantly reduce the donor exposure.