Management of diverticular disease is changing
Management of diverticular disease is changing
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DOI：
10.3748/wjg.v12.i20.3225
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发表时间：
2006-05-28
影响因子：
4.3
通讯作者：
White, Jonathan A.
中科院分区：
文献类型：
--
作者：
Floch, Martin H.;White, Jonathan A.
结肠憩室病主要是一种生活在西化和工业化国家的人类的疾病。生活在工业化国家的60%的人会患上结肠憩室。它在40岁之前很少见，但当发生在年轻人时更容易发生并发症。到80岁时，超过65%的人患有结肠憩室。病因尚不清楚，但流行病学研究将其归因于膳食纤维缺乏。憩室炎的原因尚不清楚，但新的观察和假设表明，它是由于肠壁的慢性炎症。标准的肠道休息和抗生素治疗仍然是推荐的治疗方法。然而，不断变化的概念和新的治疗方法表明，抗炎药物如美沙拉明和可能的益生菌可能有助于缩短病程，或许还可以防止复发。严重急性疾病穿孔的标准外科治疗方法已被开发出来，因此推荐采用两阶段手术。此外，腹腔镜手术已被证明是安全的，可能会慢慢成为首选技术。(C)2006年WJG出版社。版权所有。
Diverticular disease of the colon is primarily a disease of humans living in westernized and industrialized countries. Sixty percent of humans living in industrialized countries will develop colonic diverticula. It is rare before the age of 40, but more prone to complications when it occurs in the young. By age 80, over 65% of humans have colonic diverticula. The cause remains uncertain, but epidemiologic studies attribute it to dietary fiber deficiency. The cause of diverticulitis remains uncertain, but new observations and hypotheses suggest that it is due to chronic inflammation in the bowel wall. Standard medical therapies of bowel rest and antibiotics are still the recommended treatment. However, changing concepts and new therapies indicate that anti-inflammatory agents such as mesalamine and possibly probiotics may be helpful in shortening the course and perhaps preventing recurrences. Standard surgical treatment for perforation for severe acute disease has developed so that two-stage procedures are recommended. In addition, laparoscopic surgery has proven safe and may slowly become the technique of choice. (C) 2006 The WJG Press. All rights reserved.