Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis:: In vivo evidence of a role for nerve growth factor
Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis:: In vivo evidence of a role for nerve growth factor
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DOI：
10.1073/pnas.95.6.3209
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发表时间：
1998-03-17
影响因子：
11.1
通讯作者：
Aloe, L
中科院分区：
文献类型：
--
作者：
Calzà, L;Giardino, L;Aloe, L
成年大鼠脑室下区（SVZ）中的增殖细胞可以为退行性疾病期间的修复尝试提供细胞来源。然而，很少有报告涉及实验条件下该细胞群的自发调节。在本文中，我们描述了实验性过敏性脑脊髓炎期间 SVZ 增殖活性的增加，这是一种广泛用作人类多发性硬化症实验模型的脱髓鞘疾病。此外，与对照组相比，实验性变应性脑脊髓炎中SVZ中的p75(LNGFR)免疫反应元件更大，并且还表现出多重和分支的伸长。最后，在新生大鼠的SVZ中观察到I-125神经生长因子的选择性摄取，并且阳性元素在几天内迁移到胼胝体中。这些数据表明，SVZ 中数量的下降在炎症条件和涉及少突胶质细胞和神经营养因子（包括神经生长因子）的退行性疾病期间受到调节，可能参与这些现象。
Proliferating cells in the subventricular zone (SVZ) of adult rat brain could provide a source of cells for repair attempts during degenerative diseases. However, very few reports dealt with the spontaneous regulation of this cell population during experimental conditions. In this paper, we describe an increase in the proliferation activity in the SVZ during experimental allergic encephalomyelitis, a demyelinating disease widely used as an experimental model for human multiple sclerosis. Moreover, p75(LNGFR)-immunoreactive elements in the SVZ were larger in experimental allergic encephalomyelitis compared with control groups, and they also showed multiple and branched elongations. Finally, a selective uptake of I-125-nerve growth factor was observed in the SVZ in neonatal rats, and positive elements migrated in the corpus callosum within a few days. These data indicate that fell populations in the SVZ are regulated during inflammatory conditions and degenerative diseases involving oligodendrocytes and neurotrophins, including nerve growth factor, could participate in these phenomena.