Changes in arterial wall properties during development and maintenance of renal hypertension.
Changes in arterial wall properties during development and maintenance of renal hypertension.
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肾性高血压发生和维持期间动脉壁特性的变化。
DOI：
10.1152/ajpheart.1982.242.3.h477
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Cox,RH
中科院分区：
文献类型：
--
作者：
Cox,RH
采用颈动脉和尾动脉血管段，研究了两肾Goldblatt高血压对血管力学性能和化学成分的影响。在高血压4和12周后获得动脉。对照组动物的平均收缩压为129 mmHg，高血压组为150 mmHg。在主动（145 mM K+）和被动（0 Ca 2+和2 mM EGTA）平滑肌条件下记录压力-直径数据。4和12周后，高血压动物的颈动脉被动僵硬度略有增加，但尾动脉无明显变化。小，但显着减少，总结缔组织含量的这些动脉后12周的高血压。主动应激反应的最大值显着更大的高血压动物的颈动脉在4和12周的高血压。尾动脉无显著差异。高血压动物的颈动脉而不是尾动脉的K+含量较大。当校正相对细胞含量的差异时，主动力发展的大部分差异被消除。被动力学的差异不能用结缔组织含量的变化来解释。主动平滑肌反应和含量的变化表明，它们与动脉压的中度升高直接相关。
Segments of carotid and tail arteries were used to determine the effects of two-kidney Goldblatt hypertension on mechanical properties and chemical contents. Arteries were obtained after 4 and 12 wk of hypertension. Systolic pressures averaged 129 mmHg in control animals and 150 mmHg in hypertensive ones. Pressure-diameter data were recorded under conditions of active (145 mM K+) and passive (0 Ca2+ and 2 mM EGTA) smooth muscle. Small increases in passive stiffness were found after 4 and 12 wk in the carotid arteries of hypertensive animals, but no significant change occurred in the tail arteries. Small but significant decreases in total connective tissue content of these arteries were found after 12 wk of hypertension. Maximum values of active stress response were significantly larger in carotid arteries from hypertensive animals at both 4 and 12 wk of hypertension. No significant differences were found for the tail arteries. The K+ content of the carotid but not the tail artery was larger for the hypertensive animals. When corrected for differences in relative cell content most of the differences in active force development were eliminated. The differences in passive mechanics can not be explained on the basis of the changes in connective tissue content. The active smooth muscle responses and content changes suggest that they are directly related to the moderate elevation of arterial pressure.