Cocaine use can increase cigarette smoking: evidence from laboratory and naturalistic settings.
Cocaine use can increase cigarette smoking: evidence from laboratory and naturalistic settings.
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使用可卡因会增加吸烟量：来自实验室和自然环境的证据。
DOI：
10.1037//1064-1297.5.3.263
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发表时间：
1997
影响因子：
2.3
通讯作者：
Tidey,J
中科院分区：
文献类型：
--
作者：
Roll,JM;Higgins,ST;Tidey,J
两项研究调查了可卡因使用对吸烟的影响。研究1在受控实验室条件下对10名健康志愿者进行。参与者在单独的阶段接受双盲剂量的鼻内可卡因HCl（100 mg）或安慰剂，每个阶段之后是3小时的监测吸烟期。可卡因给药后，第一支香烟的潜伏期和两支香烟之间的平均间隔显著缩短，吸烟总数大于安慰剂给药后。研究2使用9例非卧床可卡因依赖患者的尿液标本进行。将尿分析检测表明最近使用可卡因的日子的尿可替宁（尼古丁代谢物）水平与尿分析检测表明最近未使用的日子的水平进行比较。可卡因阳性日的可替宁水平显著较高，表明可卡因的使用与更多的吸烟有关。总体结果提供了证据表明，急性可卡因管理可以增加吸烟。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Two studies examined the effects of cocaine use on cigarette smoking. Study 1 was conducted with 10 healthy volunteers under controlled laboratory conditions. Participants received double-blind doses of intranasal cocaine HCI (100 mg) or placebo in separate sessions, with each being followed by a 3-hr period of monitored cigarette smoking. Latency to the first cigarette and the mean interval between cigarettes was significantly shorter and the total number of cigarettes smoked was greater after cocaine than placebo administration. Study 2 was conducted by using urine specimens from 9 ambulatory cocaine-dependent patients. Urine cotinine (nicotine metabolite) levels on days when urinalysis testing indicated recent cocaine use were compared with levels on days when urinalysis testing indicated no recent use. Cotinine levels were significantly higher on cocaine-positive days, indicating that cocaine use was associated with greater cigarette smoking. Overall results provide evidence that acute cocaine administration can increase cigarette smoking.(PsycINFO Database Record (c) 2016 APA, all rights reserved)