Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases
Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases
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DOI：
10.1039/c0cc00585a
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Faber, Kurt
中科院分区：
文献类型：
--
作者：
Fuchs, Michael;Koszelewski, Dominik;Faber, Kurt
A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various omega-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine.
