Effect of Sustained Inflation Length on Establishing Functional Residual Capacity at Birth in Ventilated Premature Rabbits
Effect of Sustained Inflation Length on Establishing Functional Residual Capacity at Birth in Ventilated Premature Rabbits
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DOI：
10.1203/pdr.0b013e3181b1bca4
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发表时间：
2009-09-01
影响因子：
3.6
通讯作者：
Hooper, Stuart B.
中科院分区：
文献类型：
--
作者：
te Pas, Arjan B.;Siew, Melissa;Hooper, Stuart B.
研究充气长度对出生后即刻肺充气模式、潮气量和功能残气量(FRC)的影响。早产兔(28d)随机分为4组，分别给予1、5、10、20-S充气(SI)，然后以5 cm H2O呼气末压力进行机械通气。用体积描记法测量肺气量，用X射线相衬成像测量肺充气均匀度，持续7min。首次吸气量(p<；0.001)随充气时间的延长而显著增加，1-S充气的中位数为0.2mL/kg，20-S充气的中位数为23.4mL/kg。肺充气均匀，20-S SI后FRC和潮气量完全充盈。10-S SI在7分钟时引起更高的FRC(p<；0.05)，20-S SI在20 S和7分钟时引起更高的FRC(p<；0.05)。当充气压力为35 cm时，90%的肺平均充气时间(SD)为14.0(4.1)S。在这些兔中，10-和20-S SI增加了吸气量并产生了更大的FRC，20-S SI在开始换气前均匀地给肺充气。(儿科研究66：295-300,2009)
The effect of inflation length on lung aeration pattern, tidal volumes, and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 d), randomized into four groups, received a 1-, 5-, 10-, or 20-s inflation (SI) followed by ventilation with 5 cm H2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast x-ray imaging for 7 min. The first inspiratory volume significantly (p < 0.001) increased with inflation duration from a median (IQR) of 0.2 (0.1-3.1) mL/kg for 1-s inflation to 23.4 (19.3-30.4) mL/kg for 20-s SI. The lung was uniformly aerated, and the FRC and tidal volume fully recruited after 20-s SI. A 10-s SI caused a higher FRC (p < 0.05) at 7 min, and a 20-s SI caused a higher FRC (p < 0.05) at 20 s and 7 min than a 1- or 5-s SI. The mean (SD) time for 90% of the lung to aerate was 14.0 (4.1) s using 35 cm H2O peak inflation pressure. In these rabbits, 10- and 20-s SI increased the inspiratory volume and produced a greater FRC, and a 20-s SI uniformly aerated the lung before ventilation started. (Pediatr Res 66: 295-300,2009)