Carotid body denervation eliminates apnea in response to transient hypocapnia.
Carotid body denervation eliminates apnea in response to transient hypocapnia.
复制标题
颈动脉体去神经可以消除短暂性低碳酸血症引起的呼吸暂停。
DOI：
10.1152/japplphysiol.00722.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Dempsey,JeromeA
中科院分区：
文献类型：
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作者：
Nakayama,Hideaki;Smith,CurtisA;Rodman,JoshuaR;Skatrud,JamesB;Dempsey,JeromeA
我们确定了呼吸的影响，短暂的呼吸过冲和伴随的低碳酸血症，压力支持机械通气（PSV），在完整的和颈动脉体化学感受器去神经（CBX）睡眠狗。在完整的狗中，PSV诱导的潮气量和低碳酸血症的短暂增加在10-11秒内引起呼吸暂停，随后是由呼吸暂停分开的重复的两次呼吸簇，即，周期性呼吸（PB）。CBX后，直到PSV诱导的低碳酸血症30 s后才出现显著的呼气时间延长，PB从未发生。呼吸过冲后平均呼吸暂停持续时间为8.4 ± 1-s，要求潮气末Pco降低至正常呼吸以下，正常动物为正常呼吸以下25.1 ± 0.4 Torr，CBX犬为正常呼吸以下10.1 ± 2 Torr，其中前者反映外周和后者反映中枢动态CO2化学反应性，如在无外周化学感受器输入的情况下测试的。当犬完整时，高氧缩短了PSV诱导的呼吸暂停并减少了PB，但没有模仿CBX的作用。我们的结论是，在非快速眼动睡眠，颈动脉化学感受器需要产生呼吸暂停，通常发生在短暂的过度兴奋和PB。
We determined the effects on breathing of transient ventilatory overshoots and concomitant hypocapnia, as produced by pressure support mechanical ventilation (PSV), in intact and carotid body chemoreceptor denervated (CBX) sleeping dogs. In the intact dog, PSV-induced transient increases in tidal volume and hypocapnia caused apnea within 10–11 s, followed by repetitive two-breath clusters separated by apneas, i.e., periodic breathing (PB). After CBX, significant expiratory time prolongation did not occur until after 30 s of PSV-induced hypocapnia, and PB never occurred. Average apneas of 8.4 ± 1-s duration after a ventilatory overshoot required a decrease below eupnea of end-tidal Pco25.1 ± 0.4 Torr below eupnea in the intact animal and 10.1 ± 2 Torr in the CBX dog, where the former reflected peripheral and the latter central dynamic CO2chemoresponsiveness, as tested in the absence of peripheral chemoreceptor input. Hyperoxia when the dogs were intact shortened PSV-induced apneas and reduced PB but did not mimic the effects of CBX. We conclude that, during non-rapid eye movement sleep, carotid chemoreceptors are required to produce apneas that normally occur after a transient ventilatory overshoot and for PB.