SEGMENTAL PERFUSION OF THE CORONARY ARTERIES WITH FIBRINOLYSIN IN MAN FOLLOWING A MYOCARDIAL INFARCTION
SEGMENTAL PERFUSION OF THE CORONARY ARTERIES WITH FIBRINOLYSIN IN MAN FOLLOWING A MYOCARDIAL INFARCTION
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DOI：
10.1016/0002-9149(60)90348-9
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发表时间：
1960-01-01
影响因子：
2.8
通讯作者：
MURPHY, WP
中科院分区：
文献类型：
--
作者：
BOUCEK, RJ;MURPHY, WP
酶消化冠状动脉血栓形成的可能性已经引起了研究人员的关注。过去曾尝试通过外科手术打开阻塞的冠状动脉段，将外周动脉移植到心肌中，或刺激心包毛细血管生长到心肌中，以补充缺血心肌的血液供应。这些在外科和医学治疗方法方面的进展是有希望的。然而，酶消化冠状动脉血栓的想法引发了一系列新的问题，需要新的答案。这些问题中最根本的是闭塞性冠状动脉疾病的实际发病机制。临床医生暗示，大多数冠状动脉闭塞是由血栓引起的。医院病理学家报告说，心肌梗死背后存在明显的冠状动脉闭塞的频率为所有检查心脏的40%到80%。这种广泛的范围是不同的冠状动脉检查技术的结果，粗略的冠状动脉尸检研究显示大约40%的冠状动脉闭塞，美国？而更复杂的注射方法会显示80%的梗阻吗？然而，这只是所需信息的一部分。
R the possibility of enzymatic digestion of a coronary thrombosis has captured the i~ lagination of investigators. Attempts have been made in the past to supplement the blood supply of an ischemic myocardium by surgically opening the obstructed coronary segment,’transplanting a peripheral artery into the heart muscle, z or stimulating the pericardial capillaries to grow into the myocardium.” These advances in the surgical and medical approaches to therapy are promising. However, the idea of enzymatic digestion of a coronary thrombosis spawns a host of new questions which require new answers.‘The most fundamental of these questions is the actual pathogenesis of occlusive coronary arterial disease. The clinician implies that most coronary occlusions result from a thrombus. Hospital pathologists report the frequency of demonstrable coronary-occlusion underlying a myocardial infarction as 40 to 80 per cent of all hearts examined. This wide range is the result of different technics for coronary examination, Cursory postmortem studies of the coronary arteries demonstrate occlusion in approximately 40 per cent, u? hile the more elaborate injection methods show obstruction in 80 per cent? However, this is only one part of the needed information.