The effect of inhaled histamine on human tracheal mucus velocity and bronchial mucociliary clearance.
The effect of inhaled histamine on human tracheal mucus velocity and bronchial mucociliary clearance.
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吸入组胺对人气管粘液速度和支气管粘液纤毛清除的影响。
DOI：
10.1164/ajrccm/138.4.775
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lourenco,RV
中科院分区：
文献类型：
--
作者：
Mussatto,DJ;Garrard,CS;Lourenco,RV
本文用放射性气雾剂技术在6名健康人中进行了随机、双盲、交叉研究，观察了吸入组胺对人气管粘液流速（TMV）和支气管粘液清除率（CB）的影响。受试者在吸入放射性气雾剂后立即和随后的2.5小时清除率测量期间重复吸入磷酸盐缓冲盐水（PBS）或组胺。组胺的给药浓度先前已证明可诱导FEV1下降20%，给药间隔允许90%恢复（平均恢复时间= 25 min）。吸入组胺后TMV和CB均显著增加（p< 0.001）。
The effect of Inhaled histamine on human tracheal mucus velocity (TMV) and bronchial mucocillary clearance (CB) was Investigated In six healthy sUbjects using radloaerosol techniques in a randomized double-blind crossover study. Subjects Inhaled repeated doses of either phosphatebuffered saline (PBS) or histamine, Immediately after the Inhalation of a radioaerosol and during the subsequent 2.5-h clearance measurements. Histamine was administered in concentrations previously demonstrated to Induce a 20% fall In FEV1 at Intervals permitting 90% recovery (mean recovery time= 25 min). Both TMV and CB were significantly increased by Inhaled histamine (p< 0.001).