Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique
Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique
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DOI：
10.1088/1758-5082/1/2/025003
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发表时间：
2009-06-01
期刊：
影响因子：
9
通讯作者：
Wang, Xiaohong
中科院分区：
文献类型：
--
作者：
Kai, He;Wang, Xinluan;Wang, Xiaohong
骨巨细胞瘤（GCT）切除后，需要用足够的生物材料填充缺损。以磷酸化壳聚糖（P-壳聚糖）和（1 -> 4）-2-脱氧-2-磺胺基-β-D-吡喃糖醛酸二钠（S-壳聚糖）作为聚乳酸-乙醇酸共聚物的添加剂，开发出一种既刺激成骨细胞生长又抑制破骨细胞活性的新型功能性骨修复材料 基于双喷嘴低温沉积制造技术的（PLGA）/磷酸钙（TCP）支架。使用计算机辅助设计模型，并通过纯 PLGA/TCP 系统的操作确定最佳制造参数。对不同P-壳聚糖和S-壳聚糖浓度的样品的微观结构、吸水性和力学性能进行了相应的表征。结果表明，这种独特的复合多孔支架材料是修复手术切除 GCT 后大骨缺损的潜在候选材料。
After the removal of the giant cell tumor (GCT) of bone, it is necessary to fill the defects with adequate biomaterials. A new functional bone repair material with both stimulating osteoblast growth and inhibiting osteoclast activity has been developed with phosphorylated chitosan (P-chitosan) and disodium (1 -> 4)-2-deoxy-2-sulfoamino-beta-D-glucopyranuronan (S-chitosan) as the additives of poly(lactic acid-co-glycolic acid) (PLGA)/calcium phosphate (TCP) scaffolds based on a double-nozzle low-temperature deposition manufacturing technique. A computer-assisted design model was used and the optimal fabrication parameters were determined through the manipulation of a pure PLGA/TCP system. The microscopic structures, water absorbability and mechanical properties of the samples with different P-chitosan and S-chitosan concentrations were characterized correspondingly. The results suggested that this unique composite porous scaffold material is a potential candidate for the repair of large bone defects after a surgical removal of GCT.