Excisanin h, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa
Excisanin h, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa
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DOI：
10.1021/np030357r
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发表时间：
2004-03-01
影响因子：
5.1
通讯作者：
Takeya, K
中科院分区：
文献类型：
--
作者：
Gui, MY;Aoyagi, Y;Takeya, K
从离叶香茶菜（Rabdosia excisa）地上部分中分离得到一个新的14，20-环氧-对映贝壳杉烯二萜化合物excisanin H（1）和三个新的对映贝壳杉烯二萜化合物2-4，以及八个已知的对映贝壳杉烯二萜化合物5-12。使用光谱（HREIMS、IR、H-1、C-13和2D NMR）方法进行结构解析。1的绝对构型是通过证明kamebakaurin（8）氧化生成exisanin H（1）来确定的。这些对映贝壳杉烯二萜类化合物对P388小鼠白血病细胞均表现出明显的细胞毒活性。
A novel 14,20-epoxy-ent-kaurene diterpenoid, excisanin H (1), and three new ent-kaurene diterpenoids, 2-4, were isolated from aerial parts of Rabdosia excisa along with eight known ent-kaurene diterpenoids, 5-12. The structural elucidations were made using spectral (HREIMS, IR, H-1, C-13, and 2D NMR) methods. The absolute configuration of 1 was determined by demonstrating that oxidation of kamebakaurin (8) produced excisanin H (1). These ent-kaurene diterpenoids all showed significant cytotoxic activity against P388 murine leukemia cells.