A HUMAN MALIGNANT CELL LINE ESTABLISHED FROM ASCITES OF PATIENT WITH EMBRYONAL CARCINOMA OF OVARIUM
A HUMAN MALIGNANT CELL LINE ESTABLISHED FROM ASCITES OF PATIENT WITH EMBRYONAL CARCINOMA OF OVARIUM
复制标题
卵巢胚胎癌患者腹水建立的人类恶性细胞系
DOI：
10.1111/j.1440-1827.1975.tb00152.x
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
K. Nishitani
中科院分区：
文献类型：
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作者：
T. Kimoto;A. Ueki;K. Nishitani
在我们尝试从癌症患者的各种腹水中建立癌细胞系时，成功地从患有原发性卵巢肿瘤（胚胎癌）的63岁女性的腹水中建立了细胞系。由于转移，腹膜的组织学结果似乎是囊腺癌，显示分化为形成粗糙网络和纤维的非上皮细胞，组织培养物的形态学变化也反映了这种组织学结果。目前传代培养已达到第95代群体倍增水平，培养细胞已呈现间皮细胞或成纤维细胞的形态，约有50条染色体。作为人恶性细胞系，它可用于人恶性肿瘤细胞的研究，ACTA PATH.JAP.25：89-98，1975。
In our attempts at establishing a cancer cell line from various ascites of cancer bearing patients, a cell line was successfully established from the ascites of a 63‐year‐old female with primary ovarian tumor (embryonal carcinoma). Histological flndings of the peritoneum, due to metastasis, appeared to be cystadenocarcinoma, revealing the differentiation to non‐epitheual cells which formed coarse networks and fibers, and morphologic changes of tissue cultures also reflected such histologic findings. At present the subculture has reached the 95th population doubling level, and cultured cells have assumed the morphology of mesothelial cells or flbroblasts with about 50 chromosomes. As a human malignant cell line, it is useful for the study of human malignant tumor cell, ACTA PATH. JAP. 25: 89–98, 1975.