Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies.
Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies.
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DOI：
10.3177/jnsv.59.213
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发表时间：
2013
影响因子：
1.6
通讯作者：
Jinyao Chen;Yang Song;Lishi Zhang
中科院分区：
文献类型：
--
作者：
Jinyao Chen;Yang Song;Lishi Zhang
番茄红素/番茄已被认为是预防和治疗前列腺癌的潜在效应物；然而，最近没有报道系统评价来说明其效果。在本研究中，进行了一项荟萃分析，以确定摄入番茄红素和番茄/番茄制品是否可以降低患前列腺癌的风险。通过检索国际期刊数据库和相关出版物的参考文献列表，确定了十一项队列研究和六项巢式病例对照研究。两名评审员独立评估研究质量并从每项确定的研究中提取数据；只有具有足够质量的研究才会被纳入审查。感兴趣的主要结果是前列腺癌的发病率。与生番茄摄入量较低的消费者相比，生番茄摄入量较高的消费者前列腺癌发病率的比值比 (OR) 为 0.81 [95% 置信区间 (CI) 0.59-1.10]；对于较高水平熟番茄摄入量与较低水平熟番茄摄入量的消费者，该 OR 为 0.85 (95% CI 0.69-1.06)；前列腺癌中番茄红素摄入量较高与番茄红素摄入量较低的 OR 为 0.93 (95% CI 0.86-1.01)，血清番茄红素水平较高与血清番茄红素水平较低的 OR 为 0.97 (95% CI 0.88-1.08)。研究表明，番茄可能在预防前列腺癌方面发挥一定作用。需要进一步研究来确定番茄产品的类型和数量，了解其预防前列腺癌的潜力。
Lycopene/tomato has been discussed as a potential effecter in the prevention and therapy of prostate cancer; however, no systematic review has been reported to illustrate its effect recently. In the present study, a meta-analysis was carried out to determine whether intake of lycopene and tomato/tomato products could reduce the risk of prostate cancer. Eleven cohort studies and six nested case-control studies were identified through searching of international journal databases and reference lists of relevant publications. Two reviewers independently assessed the study quality and extracted data from each identified study; only studies with sufficient quality were included in the review. The main outcome of interest was incidence of prostate cancer. Compared with consumers of lower raw tomato intake, the odds ratio (OR) of incidence of prostate cancer among consumers of higher raw tomato intake was 0.81 [95% confidential interval (CI) 0.59-1.10]; for consumers of higher level of cooked tomato intake versus lower cooked tomato intake, this OR was 0.85 (95% CI 0.69-1.06); the OR of higher lycopene intake versus lower lycopene intake for prostate cancer was 0.93 (95% CI 0.86-1.01) and the OR for higher level of serum lycopene versus lower serum lycopene level was 0.97 (95% CI 0.88-1.08). It's suggested that tomato may play a modest role in the prevention of prostate cancer. Further research would be needed to determine the type and quantity of tomato products regarding their potential in preventing prostate cancer.