Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents
Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents
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DOI：
10.1006/mthe.2002.0702
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发表时间：
2002-10-01
影响因子：
12.4
通讯作者：
Tolentino, MJ
中科院分区：
文献类型：
--
作者：
Auricchio, A;Behling, KC;Tolentino, MJ
新生血管的特征是糖尿病视网膜病变和脉络膜新生血管与年龄相关性黄斑变性相关，这是发达国家严重视力丧失的最常见原因。用腺相关病毒(AAV)载体将基因转移到眼睛是治疗遗传性和获得性眼部疾病的一种很有前途的新方法。在早产儿视网膜病变的小鼠模型中，我们使用快速起效和视网膜高水平基因表达的AAV载体将三种抗血管生成因子(色素上皮衍生因子、金属蛋白酶组织抑制因子-3和内皮抑素)输送到小鼠的眼睛。这三种载体都能抑制缺血诱导的新生血管。
Neovascularization characterizes diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration, the most common causes of severe visual loss in the developed world. Gene transfer to the eye using adeno-associated viral (AAV) vectors is a promising new treatment for inherited and acquired ocular diseases. We used an AAV vector with rapid onset and high levels of gene expression in the retina to deliver three anti-angiogenic factors (pigment epithelium-derived factor, tissue inhibitor of metalloproteinase-3, and endostatin) to the eyes of mice in a mouse model of retinopathy of prematurity. All three vectors inhibited ischemia-induced neovascularization.