Type 1 diabetes.
Type 1 diabetes.
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DOI：
10.1016/s0140-6736(13)60591-7
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发表时间：
2014-01-04
期刊：
影响因子：
168.9
通讯作者：
Michels, Aaron W.
中科院分区：
文献类型：
--
作者：
Atkinson, Mark A.;Eisenbarth, George S.;Michels, Aaron W.
在过去的十年中，关于1型糖尿病的发病机制和自然史的知识有了实质性的增长，特别是在疾病预测和异质性、胰腺病理和流行病学方面。胰岛素泵和连续血糖监测仪的技术改进帮助1型糖尿病患者管理终身胰岛素管理的挑战。还发现了有望避免使人衰弱的疾病相关并发症的药物。然而，尽管在组织、智力和财政方面进行了广泛的投资，但仍没有预防或治疗1型糖尿病的手段，而且在全球范围内，糖尿病管理的质量仍然参差不齐。本次研讨会讨论了1型糖尿病的流行病学、病理学、诊断和治疗方面的最新进展，并展望了1型糖尿病患者的未来。
Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identified. However, despite broad organisational, intellectual, and fiscal investments, no means for preventing or curing type 1 diabetes exists, and, globally, the quality of diabetes management remains uneven. This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease.