Preparation and in vitro evaluation of a novel amphiphilic GdPCTA-[12] derivative;: a micellar MRI contrast agent
Preparation and in vitro evaluation of a novel amphiphilic GdPCTA-[12] derivative;: a micellar MRI contrast agent
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DOI：
10.1039/b211039c
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发表时间：
2003-02-21
影响因子：
3.2
通讯作者：
Klaveness, J
中科院分区：
文献类型：
--
作者：
Hovland, R;Glogård, C;Klaveness, J
合成了一种新型的两亲性GdPCTA-[12]衍生物。该复合物在具有相对低的CMC（0.15mM（25 ℃））的水溶液中形成胶束。描述了该体系的T ~（-1）弛豫率（r（1））随浓度的变化。最大T-1弛豫率为29.2 s（-1）mM（-1）（20 MHz，25 ℃），高于先前描述的胶束MRI造影剂。这种高T-1弛豫率是有利的水停留时间（τ（m））和络合物是七齿的事实的结果，允许两个水分子与钆离子配位（q = 2）。
A novel amphiphilic GdPCTA-[12] derivative has been prepared. The complex formed micelles in aqueous solution with a relatively low CMC, 0.15 mM (25 degreesC). The concentration dependent T-1-relaxivity (r(1)) of the system has been described. The maximum T-1-relaxivity, 29.2 s(-1) mM(-1) (20 MHz, 25 degreesC), was higher than for previously described micellar MRI contrast agents. This high T-1-relaxivity is a consequence of the favourable water residence time (tau(m)) and the fact that the complex is heptadentate allowing two water molecules to coordinate to the gadolinium ion (q = 2).