Glycosylation with glycosyl N-phenyltrifluoroacetimidates (PTFAI) and a perspective of the future development of new glycosylation methods
Glycosylation with glycosyl N-phenyltrifluoroacetimidates (PTFAI) and a perspective of the future development of new glycosylation methods
复制标题
糖基 N-苯基三氟亚胺酯 (PTFAI) 的糖基化以及新糖基化方法未来发展的展望。
DOI：
10.1039/c0cc00563k
复制
发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Sun, Jiansong
中科院分区：
文献类型：
--
作者：
Yu, Biao;Sun, Jiansong
近十年来，糖基N-苯基三氟乙酰亚胺(PTFAI)已被广泛应用于低聚糖和糖共轭化合物的合成。特别是，这些供体被发现在与‘武装’糖供体、酮糖供体和较少亲核受体的糖苷偶联方面具有优势。对PTFAI供体进行了全面的综述，以期从一个特定的角度反映糖基化化学的现状和未来趋势。
The glycosyl N-phenyltrifluoroacetimidates (PTFAI) have within the last ten years been applied in the synthesis of a wide variety of the oligosaccharides and glycoconjugates. Especially, these donors are found advantageous in glycosidic coupling with 'arming' sugar donors, ketose donors, and with less nucleophilic acceptors. A comprehensive review of the PTFAI donors is provided in a hope to reflect from a particular angle the current status and future trend of the glycosylation chemistry.