Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study
Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study
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DOI：
10.1002/jbio.202200062
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发表时间：
2022-07-06
影响因子：
2.8
通讯作者：
Kuchimaru，Takahiro
中科院分区：
文献类型：
--
作者：
Nishizawa，Nozomi;Kuchimaru，Takahiro
使用蒙特卡罗方法通过计算研究通过圆偏振光散射对早期胃癌肿瘤侵袭的定量深度估计。利用人类胃壁及其癌的光学参数，在宽光谱范围内计算从伪健康组织和癌组织散射的光的强度和圆偏振。在波长 600 nm 和 950 nm 处获得了具有相反符号的圆偏振的巨大差异以及大强度。在这两个波长下，可以通过调整检测角度来调节生物组织的采样深度。在健康层上有癌变层的双层假组织中，反之亦然，散射光的圆偏振程度根据癌变层的厚度和深度而显示出系统性变化，这表明体内定量估计早期胃癌癌症进展的可行性。
Quantitative depth estimation of tumor invasion in early gastric cancer by scattering of circularly polarized light is computationally investigated using the Monte Carlo method. Using the optical parameters of the human stomach wall and its carcinoma, the intensity and circular polarization of light scattered from pseudo‐healthy and cancerous tissues were calculated over a wide spectral range. Large differences in the circular polarization with opposite signs, together with the large intensity, are obtained at wavelengths 600 nm and 950 nm. At these two wavelengths, the sampling depth of the biological tissues can be modulated by tuning the detection angle. In bi‐layered pseudo‐tissues with a cancerous layer on a healthy layer and vice versa, the degree of circular polarization of scattered light shows systematic changes depending on the thickness and depth of the cancerous layer, which indicates the feasibility of in vivo quantitative estimation of cancer progression in early gastric cancer.