In vivo IVUS-based 3-D fluid-structure interaction models with cyclic bending and anisotropic vessel properties for human atherosclerotic coronary plaque mechanical analysis.
In vivo IVUS-based 3-D fluid-structure interaction models with cyclic bending and anisotropic vessel properties for human atherosclerotic coronary plaque mechanical analysis.
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DOI：
10.1109/tbme.2009.2025658
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Yang C;Bach RG;Zheng J;Naqa IE;Woodard PK;Teng Z;Billiar K;Tang D
在本文中，建模方法结合在体内血管内超声（IVUS）成像，计算建模，血管造影，和机械测试，提出了对人类冠状动脉粥样硬化斑块进行机械分析，潜在的更准确的斑块易损性评估。从一名患者中采集了冠状动脉斑块的44层体内IVUS数据集，并基于数据构建了四个具有流体-结构相互作用（FSI）的3-D模型，以量化各向异性血管特性和冠状动脉斑块循环弯曲对流动和斑块应力/应变条件的影响。与各向同性模型相比（模型1，无弯曲，无轴向拉伸），最大应力-P1具有最大弯曲的切割表面上的（最大主应力）值（如适用）来自模型2（各向异性，无弯曲，无拉伸），模型3模型4（各向异性，弯曲，无拉伸）和模型4（各向异性，弯曲和拉伸）分别比模型1高63%、126%和345%。循环弯曲对流动行为的影响是适度的（5%-15%）。我们的初步结果表明，在体内IVUS为基础的FSI模型与循环弯曲和各向异性材料的属性，可以提高斑块的应力/应变预测和斑块脆弱性评估的准确性。需要大规模的患者研究来进一步验证我们的发现。
In this paper, a modeling approach combining in vivo intravascular ultrasound (IVUS) imaging, computational modeling, angiography, and mechanical testing is proposed to perform mechanical analysis for human coronary atherosclerotic plaques for potential more accurate plaque vulnerability assessment. A 44-slice in vivo IVUS dataset of a coronary plaque was acquired from one patient, and four 3-D models with fluid–structure interactions (FSIs) based on the data were constructed to quantify effects of anisotropic vessel properties and cyclic bending of the coronary plaque on flow and plaque stress/strain conditions. Compared to the isotropic model (model 1, no bending, no axial stretch), maximum stress-P1 (maximum principal stress) values on the cut surface with maximum bending (where applicable) from model 2 (anisotropic, no bending, no stretch), model 3 (anisotropic, with bending, no stretch), and model 4 (anisotropic with bending and stretch) were, respectively, 63%, 126%, and 345% higher than that from model 1. Effects of cyclic bending on flow behaviors were modest (5%–15%). Our preliminary results indicated that in vivo IVUS-based FSI models with cyclic bending and anisotropic material properties could improve the accuracies of plaque stress/strain predictions and plaque vulnerability assessment. Large-scale patient studies are needed to further validate our findings.