Changes in muscle strength in patients with statin myalgia.
Changes in muscle strength in patients with statin myalgia.
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他汀类肌痛患者肌肉力量的变化。
DOI：
10.1016/j.amjcard.2014.07.042
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Thompson,PaulD
中科院分区：
文献类型：
--
作者：
Panza,GregoryA;Taylor,BethA;Roman,William;Thompson,PaulD
我们评估了他汀类药物肌痛患者的肌肉力量。我们确定了他汀类药物肌痛是否与肌肉功能的变化相关。肌痛与肌肉力量或肌肉功能的下降无关。他汀类药物可产生肌痛或肌肉疼痛，这可能会影响药物依从性。我们测量了他汀类药物对既往有他汀类药物肌痛患者肌力的影响。使用他汀类药物后，每秒60次的腿部等速伸展平均功率（− 8.8±10.5 NM，p= 0.02）和每秒60次的平均峰值扭矩（− 14.0±19.7 NM，p= 0.04）略有下降，但腿部力量的10个其他变量中有8个没有变化（所有p> 0.13）。握力、肌肉疼痛、呼吸交换率和日常活动也没有变化（所有p> 0.09）。总之，他汀类药物肌痛与肌肉力量或肌肉性能下降无关。
HighlightsWe assessed muscle strength in patients with statin myalgia.We determined if statin myalgia is associated with changes in muscle performance.Myalgia is not associated with decrements in muscle strength or muscle performance.Statins can produce myalgia or muscle pain, which may affect medication adherence. We measured the effects of statins on muscle strength in patients with previous statin myalgia. Leg isokinetic extension average power at 60 per second (− 8.8±10.5 NM, p= 0.02) and average peak torque at 60 per second (− 14.0±19.7 NM, p= 0.04) decreased slightly with statin use, but 8 of 10 other variables for leg strength did not change (all p> 0.13). Handgrip, muscle pain, respiratory exchange ratio, and daily activity also did not change (all p> 0.09). In conclusion, statin myalgia is not associated with reduced muscle strength or muscle performance.