Gangliosides and Modulation of Neuronal Functions

Gangliosides and Modulation of Neuronal Functions
复制标题

神经节苷脂和神经元功能的调节

DOI:
10.1007/978-3-642-71932-5
复制
发表时间:
1987
影响因子:
5
通讯作者:
H. Wiegandt
H. Wiegandt
中科院分区:
地球科学1区
文献类型:
--
作者:
H. Rahmann;H. Wiegandt

文献摘要

参考文献

被引文献

相似文献

神经节苷脂(=含有鞘糖脂的两亲性唾液酸)是所有质膜的成分,因此在脊椎动物组织中普遍存在。它们在神经元膜中特别丰富和复杂,通过其疏水性神经酰胺部分锚定在膜双层的外叶中,同时将其带负电荷的亲水性和宽敞的唾液酸寡糖残基暴露到细胞外空间(图1)。神经节苷脂与中性糖脂、糖蛋白和糖胺聚糖一起构成细胞表面的糖被。
Gangliosides (= amphiphilic sialic acid containing glycosphingolipids) are components of all plasma membranes and as such ubiquitous in vertebrate tissues. They are especially abundant and complex in neuronal membranes, where they are anchored in the outer leaflet of the membrane bilayer by their hydrophobic ceramide moiety, while exposing their negatively charged hydrophilic and spacious sialo-oligosaccharide residue into the extracellular space (Fig. 1). Together with neutral glycolipids, glycoproteins and glycosaminoglycans, gangliosides comprise the glycocalix of the cell surface.
转染人膀胱癌和肺癌 DNA 的转化 NIH 3T3 细胞的细胞表面糖脂。
DOI: 10.1002/j.1460-2075.1983.tb01741.x
发表时间: 1983
期刊: The EMBO journal
影响因子: --
作者:
Tsuchiya,S;Hakomori,S
通讯作者: Hakomori,S