Noninvasive quantification of myocardial blood flow in humans - A direct comparison of the [N-13]ammonia and the [O-15]water techniques
Noninvasive quantification of myocardial blood flow in humans - A direct comparison of the [N-13]ammonia and the [O-15]water techniques
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DOI：
10.1161/01.cir.93.11.2000
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发表时间：
1996-06-01
期刊：
影响因子：
37.8
通讯作者：
Schelbert, HR
中科院分区：
文献类型：
--
作者：
Nitzsche, EU;Choi, Y;Schelbert, HR
背景[N-13]氨已在犬研究中作为心肌血流示踪剂得到验证。[N-13]氨心肌血流量的估计值与微球和血液样品技术的估计值高度线性相关。然而，尚未将人体中[N-13]氨心肌血流量的估计值与独立技术进行比较。因此，本研究测试的假设，[N-13]氨正电子发射断层扫描技术在人类提供心肌血流量的估计与[O-35]水technology.Methods和结果A共30对正电子发射断层扫描流量测量进行了30名健康志愿者，15名志愿者进行了研究，所有休息和15腺苷诱导的充血。用[N-13]氨和[O-15]水方法估计的平均心肌血流量和局部心肌血流量相关性良好（y=0.02+1.02x，r= 0.99，P
Background [N-13]Ammonia has been validated in dog studies as a myocardial blood flow tracer. Estimates of myocardial blood flow by [N-13]ammonia were highly linearly correlated to those by the microsphere and blood sample techniques. However, estimates of myocardial blood flow with [N-13]ammonia in humans have not yet been compared with those by an independent technique. This study therefore tested the hypothesis that the [N-13]ammonia positron emission tomographic technique in humans gives estimates of myocardial blood flow comparable to those obtained with the [O-35]water technique.Methods and Results A total of 30 pairs of positron emission tomographic flow measurements were performed in 30 healthy volunteers; 15 volunteers were studied al rest and 15 during adenosine-induced hyperemia. Estimates of average and of regional myocardial blood flow by the [N-13]ammonia and the [O-15]water approaches correlated well (y=0.02+1.02x, r=.99, P