Observations on changes in blood vascular endothelium in the living animal
Observations on changes in blood vascular endothelium in the living animal
复制标题
DOI：
10.1002/aja.1000570303
复制
发表时间：
1935-11-01
影响因子：
--
通讯作者：
Clark, EL
中科院分区：
文献类型：
--
作者：
Clark, ER;Clark, EL
在正常和实验条件下，在透明的两栖动物尾巴和安装在兔耳内的小室中观察到了活的血管。条件。在以前的描述中，强调了血管内皮细胞相对于生长能力的不稳定。目前的意见表明，它在一致性方面是不稳定的。根据刺激的性质和强度，内皮细胞可能会经历以下一系列变化：阶段1。衬里光滑；血细胞滑动而不粘连。第二阶段：稠度略有变化。白血球会短暂地粘在墙上。这一阶段可能持续数小时或数天，没有白细胞迁移，也可能在任何时候恢复到阶段1。阶段3。进一步改变[长划线]白细胞更多地紧贴在壁上。可能是暂时的，并突然恢复到第二阶段。第四阶段。一致性明显较软。白血球穿壁迁移。反转到第三阶段通常发生在几个小时后，而且经常是突然的。没有血管内皮损伤的证据。损伤后血管内皮细胞的进一步变化。音调的丧失。局部部位的红细胞外渗。没有实际的墙体破裂。复苏需要相当长的时间。6期：血管内皮细胞严重损伤，室壁连续性断裂。无法恢复。内皮细胞对相对微小刺激的快速反应和初期阶段的可逆性无疑具有重要的生理学意义。
Living blood vessels were observed in transparent amphibian tails and in chambers installed in rabbits'' ears under normal and exp. conditions. In former descriptions the lability of vascular endothelium in respect to growth capacity was emphasized. The present observations demonstrated its lability in respect to consistency. Endothelium may undergo the following series of changes depending on the character and strength of the stimulus: Phase 1. Lining smooth; blood cells slip along without sticking. Phase 2. Slight change in consistency. Leukocytes stick to walls momentarily. This phase may persist for hours or days with no leukocyte emigration or may revert at any time to phase 1. Phase 3. Further change[long dash]leukocytes cling tightly to walls in larger numbers. May be transitory and revert abruptly to phase 2. Phase 4. Consistency apparently softer. Leukocytes emigrate through walls. Reversal to phase 3 usually occurs after a few hours and is frequently abrupt. No evidence of endothelial injury. Phase 5. Further change in endothelium subjected to injury. Loss of tonicity. Extravasation of erythrocytes at localized places. No actual break in wall. Recovery takes an appreciable time. Phase 6. Serious injury to endothelium with break in continuity of wall. No recovery. The rapid occurrence of changes in endothelial consistency in response to relatively minute stimuli and the reversibility of the preliminary phases are of undoubted physiological importance.