Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan
Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan
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DOI：
10.1016/s0304-3835(01)00486-4
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发表时间：
2001-06-26
期刊：
影响因子：
9.7
通讯作者：
Tominaga, S
中科院分区：
文献类型：
--
作者：
Inoue, M;Tajima, K;Tominaga, S
实验研究表明，绿色茶具有多种抗癌活性，包括抑制肿瘤侵袭和转移的作用。这项研究旨在检查诊断前定期饮用绿色茶与随后乳腺癌复发风险之间的关系。爱知癌症中心的医院流行病学研究计划（HERPACC）始于1988年，其中通过问卷定期收集所有首次就诊的门诊患者的生活方式信息。对1990年6月至1998年8月期间诊断为HERPACC信息的1160例女性浸润性乳腺癌新手术病例进行随访至1999年12月，并使用考克斯比例风险模型参考每日绿色茶消耗量评估复发风险（风险比：HR）。在5264人年的随访中，133例受试者（12%）被记录为乳腺癌复发。观察到每日饮用三杯或三杯以上绿色茶（HR = 0.69，95%置信区间（95%）=0.47-1.00），经分期调整后复发HR降低。尤其在I期，HR显著降低（HR = 0.43，95%CI = 0.22-0.84）。在II期受试者中观察到类似的趋势，但在更晚期受试者中不存在。虽然需要仔细解释，但这些结果表明，定期饮用绿色茶可能有助于预防早期乳腺癌复发。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Experimental studies suggest various features of anticancer activity of green tea including inhibitory effect of tumor invasion and metastasis. This study was conducted to examine the association between regular green tea consumption prior to diagnosis and subsequent risk of breast cancer recurrence. The Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC) was started in 1988, in which information on lifestyle has routinely been collected from all first-visit outpatients by questionnaire. A total of 1160 new surgical cases of female invasive breast cancers with HERPACC information diagnosed between June 1990 and August 1998 were followed up through December 1999, and the risk (hazard ratio: HR) of recurrence was assessed with reference to daily green tea consumption using a Cox proportional hazard model. During 5264 person-years of follow-up, 133 subjects (12%) were documented to suffer recurrence of breast cancer. A decreased HR for recurrence adjusted for stage was observed with consumption of three or more daily cups of green tea (HR = 0.69, 95% confidence interval (95%)=0.47-1.00). particularly in stage I, the HR was decreased statistically significantly (HR = 0.43, 95%CI = 0.22-0.84). A similar tendency was observed for stage II subjects, bur was not present among more advanced stages. Although careful interpretation is needed, these results suggest the possibility that regular green tea consumption may be preventive against recurrence of breast cancer in early stage cases. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.