Active Consumption of Konjac and Konjac Products Improves Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
Active Consumption of Konjac and Konjac Products Improves Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
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积极食用魔芋和魔芋产品可改善 2 型糖尿病患者的血糖控制
DOI：
10.1080/07315724.2021.2002739
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发表时间：
2021
影响因子：
3.5
通讯作者：
Yui Yano & Masamitsu Nakazato
中科院分区：
文献类型：
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作者：
Hiroaki Ueno;Naoki Haraguchi;Mayumi Azuma;Tomomi Shiiya;Tomoho Noda;Emi Ebihara;Yudai Uehira;Taisuke Uchida;Keiko Sasaba;Miyo Nakamura;Naho Uchimura;Emiko Kita;Akemi Umemura;Tomoko Nobe;Eri Sumoto;Yui Yano & Masamitsu Nakazato
目的魔芋是一种主要在亚洲国家消费的高纤维、低能量食品。尽管魔芋的成分葡甘露聚糖已被用于多项临床研究，但使用魔芋本身的报道很少。本研究探讨了积极食用魔芋对 2 型糖尿病 (T2DM) 患者的影响。方法该研究纳入了 26 名日本 T2DM 患者。建议参与者每天至少服用一次魔芋，使用免费魔芋产品（各种面条、米饭和甜点）和盘装魔芋，持续 12 周。结果 HbA1c 和空腹血糖水平显着下降，从 8.3±0.9% 显着下降到 8.0±0.8%，从 173.2±44.4 显着下降。分别为 152.8±36.7mg/dL。体重和胰岛素抵抗指数没有明显变化，但胰岛素分泌指数显着增加。血清高分子量脂联素水平显着升高。血浆生长素释放肽、瘦素和胰高血糖素样肽-1 水平分别趋于降低 (p= 0.084)、降低 (p= 0.057) 和升高 (p= 0.071)。实际魔芋摄入量与年龄呈正相关（r= 0.61，p= 0.001）。 ≥50岁患者的体重和HbA1c显着低于50岁以下患者，且变化与年龄呈显着负相关。结论积极食用魔芋及魔芋制品似乎是治疗T2DM的一种有效的多方面饮食疗法。需要更大样本量和长期的进一步研究来证实这些发现。
ObjectiveKonjac is a food mainly consumed in Asian countries with high fiber and low energy. Although glucomannan, a component of konjac, have been used for several clinical studies, there is few reports using konjac itself. This study examined the effects of the active consumption of konjac in patients with type 2 diabetes mellitus (T2DM).MethodsThe study included 26 Japanese patients with T2DM. Participants were recommended to take konjac at least once a day using free konjac products (various noodles, rice, and desserts) and plate konjac for 12 weeks.ResultsHbA1c and fasting plasma glucose levels significantly decreased from 8.3 ± 0.9% to 8.0 ± 0.8% and from 173.2 ± 44.4 to 152.8 ± 36.7 mg/dL, respectively. No significant changes were observed in body weight and insulin resistance indices, but the index for insulin secretion significantly increased. Serum high molecular weight adiponectin levels significantly increased. Plasma ghrelin, leptin and glucagon-like peptide-1 levels tended to decrease (p= 0.084), decrease (p= 0.057) and increase (p= 0.071), respectively. Actual konjac intake positively correlated with age (r= 0.61,p= 0.001). Body weight and HbA1c significantly decreased in patients aged ≥50 years than in those aged <50 years, and the changes significantly inversely correlated with age.ConclusionActive consumption of konjac and konjac products seems to be a useful dietary therapy with multifaceted action for T2DM. Further studies with greater sample size and long-term are needed to confirm these findings.