NOVEL MICROBIAL METABOLITES OF THE PHOSLACTOMYCINS FAMILY INDUCE PRODUCTION OF COLONY-STIMULATING FACTORS BY BONE-MARROW STROMAL CELLS .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE DETERMINATION
NOVEL MICROBIAL METABOLITES OF THE PHOSLACTOMYCINS FAMILY INDUCE PRODUCTION OF COLONY-STIMULATING FACTORS BY BONE-MARROW STROMAL CELLS .2. ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURE DETERMINATION
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DOI：
10.7164/antibiotics.46.1512
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发表时间：
1993-10-01
影响因子：
3.3
通讯作者：
SHIRAISHI, A
中科院分区：
文献类型：
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作者：
KOHAMA, T;NAKAMURA, T;SHIRAISHI, A
Leustroducsins (LSNs) A、B 和 C 是新型集落刺激因子 (CSF) 诱导剂，主要通过乙酸乙酯提取和制备型反相 HPLC 从钝顶链霉菌 SANK 60191 培养液中分离得到。 LSN A、B和C的分子量和分子式分别为641：C32H52O10NP、669：C34H56O10NP和669：C34H56O10NP。结构解析表明它们属于磷乳霉素类抗生素，其结构含有α，β-不饱和δ-内酯、氨基、磷酸酯和环己烷环部分。这些结构仅在与环己烷环结合的取代基上有所不同。
Leustroducsins (LSNs) A, B and C, novel inducers of colony-stimulating factors (CSFs), were isolated from culture broth of Streptomyces platensis SANK 60191 mainly by ethyl acetate extraction and preparative reverse-phase HPLC. The molecular weights and molecular formulae of LSNs A, B and C are 641: C32H52O10NP, 669: C34H56O10NP and 669: C34H56O10NP, respectively. The structure elucidation revealed that they belong to the phoslactomycin group antibiotics, and their structures contain an alpha,beta-unsaturated delta-lactone, an amino group, a phosphate ester and a cyclohexane ring moiety. The structures differ only at the substituent bound to the cyclohexane ring.