Nonalcoholic fatty liver disease and sarcopenia in a Western population (NHANES III): The importance of sarcopenia definition
Nonalcoholic fatty liver disease and sarcopenia in a Western population (NHANES III): The importance of sarcopenia definition
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DOI：
10.1016/j.clnu.2017.11.021
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发表时间：
2019-02-01
影响因子：
6.3
通讯作者：
Kao, Tung-Wei
中科院分区：
文献类型：
--
作者：
Peng, Tao-Chun;Wu, Li-Wei;Kao, Tung-Wei
背景资料：最近的流行病学研究表明，在亚洲人群中，肌肉减少症与非酒精性脂肪肝（NAFLD）和晚期纤维化相关。我们调查了NAFLD是否与使用不同的定义在老年patients.Methods：一个以人口为基础的横断面调查，美国患者，涉及2551名年龄在60-75岁的参与者的肌肉减少症的风险较高。通过超声测量NAFLD。肌肉减少症定义为肌肉质量低和肌肉功能差。此外，骨骼肌指数（SMI）计算为绝对肌肉质量（千克）除以身高（2）（米）或总体重（千克）。多变量logistic回归分析估计老年人肌肉减少症和NAFLD之间的关系。结果：在调整了年龄、性别和种族/民族后，严重的肝脂肪变性与肌肉减少症的风险降低相关，其定义为身高调整的SMI（优势比（OR）0.63; 95%可信区间（CI）0.46-0.87）。相比之下，重度肝脂肪变性与肌肉减少症风险增加相关（根据体重调整的SMI定义）（OR 1.73; 95% CI 1.31-2.28）。这些显着的协会仍然进一步调整后，其他潜在的混杂variable.Conclusions：NAFLD与低风险的肌肉减少症时，使用身高调整SMI。相比之下，当使用权重调整的SMI时，它显示出相反的结果。肌肉减少症的定义可能是检查其与NAFLD关系时的一个重要因素。(C)2017 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background: Recent epidemiological studies have shown that sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis in an Asian population. We investigated whether NAFLD is associated with a higher risk of sarcopenia using a different definition in elderly patients.Methods: A population-based cross-sectional survey of US patients was conducted, involving 2551 participants aged 60-75 years. NAFLD was measured by ultrasound. Sarcopenia was defined by both a low muscle mass and poor muscle function. In addition, the skeletal muscle index (SMI) was calculated as the absolute muscle mass (kilograms) divided by height(2) (meters) or total body mass (kilograms). A multivariable logistic regression was conducted to estimate the relationship between sarcopenia and NAFLD in the elderly.Results: After adjusting for age, sex, and race/ethnicity, severe hepatic steatosis Was associated with a decreased risk of sarcopenia as defined by the height-adjusted SMI (odds ratio (OR) 0.63; 95% confidence interval (CI) 0.46-0.87). In contrast, severe hepatic steatosis was associated with an increased risk of sarcopenia as defined by the weight-adjusted SMI (OR 1.73; 95% CI 1.31-2.28). These significant associations remained after further adjustments for other potential confounding variables.Conclusions: NAFLD is associated with a lower risk of sarcopenia when using the height-adjusted SMI. In contrast, it showed the opposite result when using the weight-adjusted SMI. The definition of sarcopenia may be an important factor when examining its relationship with NAFLD. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.