The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors
The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors
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DOI：
10.1007/s00404-008-0673-9
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发表时间：
2009-01-01
影响因子：
2.6
通讯作者：
Mollamahmutoglu, Leyla
中科院分区：
文献类型：
--
作者：
Gungor, Tayfun;Kanat-Pektas, Mine;Mollamahmutoglu, Leyla
血小板增多症在多种实体瘤中均有报道，包括某些妇科癌症，如子宫内膜癌、外阴癌和宫颈癌。本研究的目的是确定血小板增多症的发病率与卵巢上皮性肿瘤的妇女，并评估其与临床和病理预后factors.Between 2001年1月和2006年12月，292例患者被诊断为卵巢上皮性肿瘤，他们接受了主要的手术治疗和随后的铂为基础的化疗在妇科肿瘤科的研究中心。在292例接受初次手术探查的卵巢上皮性肿瘤患者中，124例（42.5%）有血小板增多症，表明血小板计数> 400 × 109/l。发现血小板增多症患者术前CA-125水平在统计学上更高，疾病更晚期，肿瘤分级更高，生存期更短。血小板增多症是影响卵巢上皮性肿瘤患者生存率的一个重要的负性预后因素。以前和现在的研究所获得的数据表明，血小板增多与反映更具侵袭性的肿瘤生物学的因素有关，并预测卵巢上皮性肿瘤妇女的生存率低。然而，这些数据受限于研究的回顾性性质，不能证实血小板增多和肿瘤行为之间的因果关系。研究血小板分泌因子表达的分子研究需要澄清文献提供的数据之间的差异。
Thrombocytosis has been reported in a variety of solid tumors, including certain gynecologic cancers such as endometrial, vulvar, and cervical cancers. The present study aims to determine the incidence of thrombocytosis in women with epithelial ovarian tumors and to evaluate its association with clinical and pathologic prognostic factors.Between January 2001 and December 2006, 292 patients were diagnosed with epithelial ovarian tumors, and they underwent primary surgical treatment and subsequent platinum-based chemotherapy at the Gynecologic Oncology Department of the study center. The medical records of these patients were evaluated retrospectively.Of the 292 women with epithelial ovarian tumors undergoing primary surgical exploration, 124 (42.5%) had thrombocytosis, indicating platelet counts > 400 x 109/l. Patients with thrombocytosis were found to have statistically higher levels of preoperative CA-125 levels, more advanced stage disease, higher grade tumors, and shorter periods of survival. Thrombocytosis is a significant negative prognostic factor for survival in patients with epithelial ovarian tumors.Thrombocytosis is frequently detected in preoperative evaluation of women diagnosed with epithelial ovarian tumors. The data obtained by the previous and present studies suggest that thrombocytosis is associated with factors reflecting a more aggressive tumor biology, and predicting poor survival in women with epithelial ovarian tumors. However, these data are limited by the retrospective nature of the studies and do not confirm a casual relationship between thrombocytosis and tumor behavior. Molecular studies investigating the expression of platelet secretory factors are required to clarify the differences among data provided by the literature.