REDUCED FECUNDABILITY IN WOMEN WITH PRENATAL EXPOSURE TO CIGARETTE-SMOKING
REDUCED FECUNDABILITY IN WOMEN WITH PRENATAL EXPOSURE TO CIGARETTE-SMOKING
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DOI：
10.1093/oxfordjournals.aje.a115211
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发表时间：
1989-05-01
影响因子：
5
通讯作者：
BAIRD, DD
中科院分区：
文献类型：
--
作者：
WEINBERG, CR;WILCOX, AJ;BAIRD, DD
动物研究表明，经胎盘暴露可能会损害生育能力，但对人类产前暴露和随后的成年生殖知之甚少。使用来自 221 名北卡罗来纳州（美国）夫妇的前瞻性研究的数据，探讨了女性产前吸烟暴露与成年生育能力之间的可能关系。这些夫妇在 1983 年至 1985 年期间被招募，当时他们为了怀孕而停止使用节育措施。通过将离散时间比例概率模型应用于逐周期受孕率来估计暴露女性与未暴露女性的相对生育能力。产前接触母亲吸烟的女性的生育能力会降低。根据年龄、性交频率、当前吸烟状况、初潮年龄和儿童时期吸烟情况进行调整后，与产前接触母亲吸烟相关的生育力比率为 0.5（95% 置信区间 0.4-0.8）。这种关联并未因其他可能的混杂变量（包括教育水平、生育史、体重以及酒精和咖啡因的摄入量）的进一步调整而改变。因此，母亲在怀孕期间吸烟的女性的平均生育能力可能大大低于母亲在怀孕期间不吸烟的女性。
Animal studies have suggested that fertility may be impaired by transplacental exposures, but little is known about human prenatal exposures and subsequent adult reproduction. A possible relation between prenatal exposure to cigarette smoking and adult fecundability in women was explored, with the use of data from a prospective study of 221 North Carolina (USA) couples. These couples were recruited during 1983-1985, at the time they stopped using birth control in order to become pregnant. The relative fecundability of exposed compared with unexposed women was estimated by aplying a discrete-time proportional probabilities model to the cycle-by-cycle conception rates. Women with prenatal exposure to their mother''s cigarette smoking had reduced fecundability. The fecundability ratio associated with prenatal exposure to mother''s smoking, adjusted for age, frequency of intercourse, current smoking status, age at menarche, and childhood exposure to cigarette smoking, was 0.5 (95% confidence interval 0.4-0.8). This association was not changed by further adjustment for other possible confounding variables, including educational level, reproductive history, body weight, and consumption of alcohol and caffeine. Thus, women whose mothers smoked while pregnant with them may be on average substantially less fecund than women whose mothers did not smoke during pregnancy.