HISTORY, SURVIVAL, AND GROWTH-PATTERNS OF B6C3F1 MICE AND F344 RATS IN THE NATIONAL CANCER INSTITUTE CARCINOGENESIS TESTING PROGRAM
HISTORY, SURVIVAL, AND GROWTH-PATTERNS OF B6C3F1 MICE AND F344 RATS IN THE NATIONAL CANCER INSTITUTE CARCINOGENESIS TESTING PROGRAM
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DOI：
10.1016/0272-0590(85)90100-9
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
TARONE, RE
中科院分区：
文献类型：
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作者：
CAMERON, TP;HICKMAN, RL;TARONE, RE
选择杂交B6 C3 F1小鼠（C57 BL/6雌性×雌性）的历史和基本原理如下：C3 h/He雄性）和近交系F344大鼠用于国家癌症研究所（NCI）生物测定。2年试验结束时的存活率和对照动物试验期间的体重增加模式，以指导研究人员在类似的长期实验中使用相同的动物。由于提供了来自多个实验室的大量动物（9385只小鼠和10，023只大鼠）的信息，因此结论应有助于为在各种饲养条件下饲养相同动物的研究者提供一般指导。该项目的经验是，B6 C3 F1小鼠在24个月结束时存活。研究（25.5个月）年龄）为80%; F344在同一时期的存活率为75%。这与人们普遍认为的大鼠比小鼠寿命更长的假设形成鲜明对比。在收集动物数据的时间段内，总体存活百分比逐渐轻微下降。这一观察结果无法解释，并且违背了生产动物的方法学改进是检测实验室中显著的物理改善的预期，这些改善应导致存活率提高。大鼠和小鼠的体重增加模式具有明显且有点相似的性二态性。每个物种的雄性在最初都长得快得多，然后基本上趋于平稳。雌性小鼠生长缓慢而稳定，到2岁时几乎与雄性相同;雌性大鼠显示出相同的稳定增长，但在2岁时比雄性轻得多。
The history of, and rationale for, the selection of the hybrid B6C3F1 mouse (C57BL/6 female .times. C3h/He male) and the inbred F344 rat for National Cancer Institute (NCI) bioassays is described. Survival percentages at the end of 2-yr tests and weight-gain patterns during the tests of control animals are presented to guide investigators using these same animals in similar long-term experiments. Because information on a large number of animals (9385 mice and 10,023 rats) from a number of laboratories is presented, the conclusions should serve to give general guidance to investigators holding the same animals under a diversity of husbandry conditions. The program experience was that the B6C3F1 mouse survival at the end of a 24-mo. study (25.5 mo. of age) is 80%; the F344 survival for the same period is 75%. This contrasts with the generally held assumption that rats are longer lived than mice. For the period of time from which animal data were collected, there was a progressively slight decrease overall in survival percentage. This observation cannot be explained, and contravenes the expectation that methodological improvements in producing the animals are marked physical improvements in the testing laboratories should have resulted in improving the survival. Weight gain patterns have a distinct and somewhat similar sexual dimorphism for both rat and mouse. The males of each species grow much faster initially and then essentially level off. The female mouse grows slowly and steadily, and by 2 yr of age almost equals the male; the female rat shows the same steady gain, but is much lighter than the male at 2 yr of age.